Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter10: Poison Control
Section: Chapter Questions
Problem 4CRQ
Related questions
Question
What is Opioid use disorder?
Expert Solution
Step 1
Opioids
- are a class of medications that function by interacting with opioid receptors in your cells to relieve pain.
- Opioids can be made naturally from the poppy plant, such as morphine (Kadian, Ms Contin, and others), or synthetically, such as fentanyl (Actiq, Duragesic, others).
MECHANISM OF ACTION
- By engaging with mu, delta, or kappa opioid receptors, opioids mimic the activities of endogenous opioid peptides.
- The opioid receptors are linked to G1 proteins, therefore opioids have primarily inhibitory effects.
- They shut N-type voltage-operated calcium channels and
- open calcium-dependent inwardly-rectifying potassium channels.
- Hyperpolarization and a decrease in neural excitability follow as a result of this.
- They also reduce intracellular cAMP, which regulates nociceptive neurotransmitter release (e.g. substance P).
- The main mechanism of analgesic action is cyclooxygenase inhibition of prostaglandin production.
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Essentials of Pharmacology for Health Professions
Nursing
ISBN:
9781305441620
Author:
WOODROW
Publisher:
Cengage
Human Physiology: From Cells to Systems (MindTap …
Biology
ISBN:
9781285866932
Author:
Lauralee Sherwood
Publisher:
Cengage Learning
Essentials of Pharmacology for Health Professions
Nursing
ISBN:
9781305441620
Author:
WOODROW
Publisher:
Cengage
Human Physiology: From Cells to Systems (MindTap …
Biology
ISBN:
9781285866932
Author:
Lauralee Sherwood
Publisher:
Cengage Learning