What role do aurora kinase play in the cell cycle and how would using these kinases as target for cancer treated work?
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What role do aurora kinase play in the cell cycle and how would using these kinases as target for cancer treated work?
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- How are cyclin dependent kinase used in the cell cycleBy what molecular pathway does loss of cell cycle regulation in an organism lead to cancer? What genetic changes can cooperate to accomplish the cancer cell’s escape from the normal balance of cell growth?What are cyclins and cyclin-dependent kinases for? Describe how do these factors affect cell proliferation.
- The expression patterns as well as activation of different types of CDKs happen at different stages of the cell cycle. Explain why.In your own words: Describe the molecular mechanisms involved in P53’s role as a tumor repressor protein.Explain Cyclin-dependent kinases (CDKs) control the cell cycle by phosphorylating other proteins?
- Describe how cyclins and cyclin-dependent kinases are related. How do these molecules help regulate the cell cycle?Why is it important to model cancer through the generation of induced pluripotent stem cells ? Explain in detail the main findings.(a) the cell cycle is divided into different phases (referred to as M, G0, G1, S and G2); Can you account for what happens during the different parts of the cycle and out of it is checked? ( b) What is the difference between apoptosis and necrosis? ( c) What are caspases and what is their function in the cell?
- Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please list item by item. Explain in detail the main findings.How does the dysregulation of cell cycle checkpoints contribute to the development of cancer?Why is it important to model cancer through the generation of induced pluripotent stem cells ? Explain in detail the main findings. Please sort as a list.
