Asked Jan 16, 2020

What type of immune response involved in systemic lupus erythematosus (SLE)?


Expert Answer

Step 1


The systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system attacks the tissues of the body which are healthy.  It is a heterogeneous disease as it has several etiologies. It involves autoreactive B and T cells that produce pathogenic autoantibodies and injury to the healthy tissues. It is characterized by the butterfly red rashes which occur commonly on the face. Its common symptoms involve chest pain, hair loss, painful and swollen joints, mouth ulcers and fatigue. There is a frequent period of illness and remission at the time these symptoms appear.

Step 2

Both innate and acquired immune responses are involved in the SLE. In this disease, innate and acquired immune responses are dysregulated. Adaptive and innate immune response induces the production of autoantibodies...

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