When the DNA sequence of the gene that codes for the peptide hormone insulin is compared in two mammals (e.g., humans and rats), most of the sequence differences are synonymous mutations. These far outnumber sequence differences that result in amino acid substitutions. Why might this be? A DNA sequence is more likely to mutate if the change does not alter the amino acid sequence. Most amino acid substitutions result in a beneficial phenotype that improves fitness and results in a greater number of offspring. Synonymous mutations occur in noncoding DNA sequences. mutations are random with respect to an organisms needs. Amino acid substitutions often result in proteins that have lost or compromised function and, therefore, are selected against.

When the DNA sequence of the gene that codes for the peptide hormone insulin is compared in two mammals (e.g., humans and rats), most of the sequence differences are synonymous mutations. These far outnumber sequence differences that result in amino acid substitutions. Why might this be? A DNA sequence is more likely to mutate if the change does not alter the amino acid sequence. Most amino acid substitutions result in a beneficial phenotype that improves fitness and results in a greater number of offspring. Synonymous mutations occur in noncoding DNA sequences. mutations are random with respect to an organisms needs. Amino acid substitutions often result in proteins that have lost or compromised function and, therefore, are selected against.

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Description: When the DNA sequence of the gene that codes for the peptide hormone insulin is compared in two mammals (e.g., humans and rats), most of the sequence differences aresynonymous mutations. These far outnumber sequence differences that result in amino

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 23QP

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