Which factors determine the resting membrane potential? Explain why the resting membrane potential is never really the value calculate by the Nernst equation for the potassium equilibrium potential.
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- Which factors determine the resting membrane potential? Explain why the resting membrane potential is never really the value calculate by the Nernst equation for the potassium equilibrium potential.
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- One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)Hyperkalemia is a condition by which ECF potassium levels become too high (usually due to kidney failure). Consider the following questions about the consequence of hyperkalemia on membrane potential. How would hyperkalemia affect EK? Considering your answer to the previous question, how would hyperkalemia affect membrane potential?
- Calculate: The equilibrium potential for potassium at room temp The equilibrium potential for sodium at room temp Resting membrane potential of this neuron at room temperature• Why would one use the Goldman-Hodgkin-Katz equation? • What is the role of the Na+/K+ pump in establishing ionic concentration differences and membrane potentials across the nerve membrane? • Describe the process of depolarization of the nerve membrane.Describe the contribution of each of the following to the establishment and maintenance of membrane potential: Part A Na+K+ Pump Passive movement of K+ across the membrane Passive movement of Na+ across the membrane Part B Resting membrane potential is approximately -70mV. Explain what resting membrane potential is and what -70mV refers to.
- Describe the action potential in terms of the different functional states of the voltage- gated Na+ membrane channels (Note: there are three states)What is the equilibrium membrane potential due to Na+ ions if the extracellular concentration of Na+ ions is 154 mM and the intracellular concentration of Na+ ions is 27 mM at 20 ∘C ? Please answer asap and in short and content should not be palgarised pleaseMatch the description with the statement that best describes the following statements hyperpolarization repolarization depolarization A. usually corresponds to opening of voltage-gated potassium channels B. any change in the membrane potential that moves the membrane potential to a value more positive than the resting potential (eg from -70mV to +35mV) C. any change in the membrane potential that moves the membrane potential to a value more negative than the resting potential (eg from -70mV to -85mV)
- Use the Goldman Equation to calculate the resting membrane potential at 37°C for each case:In the introduction section the authors wrote “In general, the polarity-dependent mechanisms are recognized to cause membrane depolarization by anodal stimulation which increases cerebral excitability, or membrane hyperpolarization by cathodal stimulation leading to a decrease in neuronal excitability.” Based on this quote what affect, if any, does anodal stimulation have on ion channels?If a particular neuron has an intracellular Chloride concentration of 154.3 mM, an extracellular Chloride concentration of 163.2 mM, and a membrane potential of -54.1, what is the net driving force (in mV) acting upon Chloride?