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(61) A 61-year old woman comes to the physician because of scarring acne vulgaris that has not been responsive to topical medication. Oral tetracycline is prescribed . Which of the following best explains the mechanism of action of this drug?
(A) Blockage of DNA gyrase
(B) Destruction of active transport membrane transport
(C) Inhibition of aminoacyl-RNA binding to bacterial ribosomes
(D) Interference with the action of peptidyl transferase
(E) Interferance with translocation reaction
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- A scientist discovers a virus encoding a Protein X that degrades a subunit of the elF4F complex. Knowing that this virus transcribes its own mRNAs in the cytoplasm of human cells, why would Protein X be an effective virulence factor?What factors ensure accuracy in protein synthesis? How does the level of accuracy usually attained in protein synthesis compare with that of replication or transcription?What steps in the elongation cycle of protein synthesis require GTP hydrolysis? What role does it play in each step?
- What is the difference between eukaryotes and prokaryotes in terms of ribosomal subunit binding?Two possible point mutations are the substitution of lysine for leucine or the substitution of serine for threonine. Which is likely to be more serious and why?I am studying pancreatic islet cells and have isolated, cloned, and sequenced a novel protein that you postulate has 4 transmembrane segments. What kind of experiment would allow me to test this hypothesis that there are 4 trans membrane segments?
- What are the four components for the translocation of protein across endoplasmic reticulum? and briefly explain ORF?22-69 Indicate whether each of the following statementsrelating to protein synthesis is true or false.a. RNA is involved in both the transcription andtranslation phases of protein synthesis.b. DNA is the starting material for protein synthesis.c. The translation phase of protein synthesis convertsRNA to DNA.d. Transcription precedes translation in proteinsynthesisWhat are the components of the initiation complex in protein synthesis? How do they interact with one another?
