Which of the following drugs is a less potent microsomal triglyceride transfer protein (MTP) inhibitor, which reduces cholesterol levels? O Structure 1 (IC50 = 23 nM) %3D O BMS-200150 (IC50 = 2.2 µM) !! O Hybrid Structure (IC50 = 12 nM) %3D O Hit compound (IC50 = 36 µM) %3D O Lomitapide (IC50 = 0.5 nM) %3D

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Which of the following drugs is a less potent microsomal triglyceride transfer protein (MTP) inhibitor,
which reduces cholesterol levels?
O Structure 1 (IC50 = 23 nM)
O BMS-200150 (IC50 = 2.2 µM)
O Hybrid Structure (IC50 = 12 nM)
%3!
O Hit compound (IC50 = 36 µM)
%3D
Lomitapide (IC50 = 0.5 nM)
Transcribed Image Text:Which of the following drugs is a less potent microsomal triglyceride transfer protein (MTP) inhibitor, which reduces cholesterol levels? O Structure 1 (IC50 = 23 nM) O BMS-200150 (IC50 = 2.2 µM) O Hybrid Structure (IC50 = 12 nM) %3! O Hit compound (IC50 = 36 µM) %3D Lomitapide (IC50 = 0.5 nM)
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