Saccharide M, a sugar made of repeating units of maltose and cellobiose, is a componentof glycoproteins 1 and 2, which are receptors found in the membrane of Shrek's cells. For glycoprotein1, saccharide M is attached by an a 1® 2 linkages to 3 sialic acid residues, then O-linked to the protein,while glycoprotein 2 has saccharide M attached by a b 1®3 bond also to 3 sialic acid residues, then it isalso O-linked to the protein. Glycoprotein 1 is a transporter protein for glucose, while glycoprotein 2 is theNa*-K*receptor/ transporter. The glycoproteins show 99% sequence homology of its amino acid sequence.a. Explain briefly why there is a difference in the functions of glycoprotein 1 and 2b. Glycoprotein 1 is a receptor for glucose. Using Benedict's reagent, tests on the glycoprotein gaveNEGATIVE results. Give 2 amino acids that can O-link with Saccharide M and show the portion of bothprotein and saccharide where a bond will be formed.

Glycoproteins are consisted of protein and glycan moiety which is involved in several biological…

Answered: Saccharide M, a sugar made of repeating…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The following data describe binding of ligand A to a protein, using both Scatchard plots and Hills plots, tell as much as you can about the binding reaction. [A](M) 1X10-6 5 X10-6 1 X10-5 5 x 10-5 1 X 10-4 5 x 10-4 1x 10-3 5X10-3 ṽ 0.101 0.381 0.591 1.116 1.409 1.813 1.899 1.955..
Lactose permease, a protein of E. coli, is composed of a singlepolypeptide that is 417 amino acids in length. By convention, theamino acids within a polypeptide are numbered from the aminoterminalend to the carboxyl-terminal end. Are the following questionsabout lactose permease true or false?A. Because the sixty-fourth amino acid is glycine and the sixty- eighth amino acid is aspartic acid, the codon for glycine,64, is closer to the 3′ end of the mRNA than the codon for aspartic acid, 68.B. The mRNA that encodes lactose permease must be greater than1241 nucleotides in length.
Can you please describe the specific components that each of these structures are comprised of ( alpha helices and beta sheets) in more detail? Also, what do the different colors represent? Your reply will be greatly appreciated. The ligand that was assigned to me is tadalafil.
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you have the following peptide Arg-Ile-Pro-Leu-Asp-Lys-Glu The net charge on this peptide at pH 7.0 is ?. The net charge on this peptide at 1M HCl is ?.
Based on the structure of CBB G-250, explain why it can bind to proteins having basic and hydrophobic amino acid residues.
Considering the chemical characteristics of the amino acids valine and glutamic acid (see Figure 5.14), propose a possible explanation for the dramatic effect on protein function that occurs when valine is substituted for glutamic acid.
Consider the following peptide: Lys-His-Asp-Glu-Phe-Cys-Ala-Asp-His-Arg What is the net charge of this peptide at pH = 1? What is the net charge of this peptide at pH = 14?
what is the difference between a ligand and a domain? I understand they both attach with proteins but how do u identify which is which? Also, what is the difference between the function of the two?
The folding of intrinsically disordered proteins is prevented by the presence of Ser, Lys, and Glu residues. What do these amino acids have in common? Why do they disrupt IDPs?
A structural difference between uracil and cystosine is: A. At C-4 cytosine has an amino group, while uracil as an oxo group B. At C-6 cytosine has an amino group, while uracil as an oxo group C. At C-4 cytosine has an amino group, while uracil as an oxo group D. Both have an oxo group at C-2 E. At C-2 cytosine has an amino group, while uracil as an oxo group
12 mM of protein A is combined with 6 mM of ligand X in water. After the protein-ligand complex binding reaches equilibrium, you measure that the free ligand concentration is 3 mM and the concentration of protein-ligand complex is 3 mM. What is the Kd for protein A? Although they would be in mM, do not include units in your answer, only the number as a whole integer.

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