Which of the following identifies the dependent variable in this experiment? A the concentration of blood lactate с D the duration of the recovery period the ingestion of oxygen supplemented water the intensity of the exercise
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- A plant breeder has developed a new frost-resistant variety of tomato that contains higher levels of unsaturated fatty acids in membrane lipids than those found in standard tomato varieties. However, when temperatures climb above 95°F, this frost-resistant variety dies, whereas the standard variety continues to grow. Provide a likely explanation of the biochemical basis of increased tolerance to cold and increased susceptibility to heat of this new tomato variety.It is not an easy matter to assign particular func-tions to specific components of the basal lamina, sincethe overall structure is a complicated composite materialwith both mechanical and signaling properties. Nidogen,for example, cross-links two central components of thebasal lamina by binding to the laminin γ-1 chain and totype IV collagen. Given such a key role, it was surprisingthat mice with a homozygous knockout of the gene fornidogen-1 were entirely healthy, with no abnormal phe-notype. Similarly, mice homozygous for a knockout of thegene for nidogen-2 also appeared completely normal. Bycontrast, mice that were homozygous for a defined muta-tion in the gene for laminin γ-1, which eliminated just thebinding site for nidogen, died at birth with severe defectsin lung and kidney formation. The mutant portion of thelaminin γ-1 chain is thought to have no other functionthan to bind nidogen, and does not affect laminin struc-ture or its ability to assemble into the basal lamina.…Two GPCR mutations (Mutant A and Mutant B) were tested for activity. One was confirmed as being a constitutively activating, gain of function GPCR mutation and one was confirmed as being a loss of function GPCR mutation. Which is which? Explain your answer.
- The alpha subunits of heterotrimeric G-proteins act as molecular timing switches. Explain the advantage of a system where the activity of a very slow enzyme, the alphs subunit, evolved to be accelerated by the effector enzymes that the GTP-bound alpha subunit stimulates. What would you predict to be the relative rate of synonymous and nonsynonymous substitutions in a globinpseudogene?What is the connection between the absence of HGPRT activity and the behavior al characteristic s of Lesch-Nyhan syndrome?
- If instead of using 3.5 µM myoglobin (receptor) you used half of this (that is, 1.75 µM myoglobin), what would be that value of the Kd, that you calculated ( how would it change)? Please explain so I can solve on my own :) (How does changing concentration of the receptor in a ligand-receptor binding experiment affect the dissociation constant?)Myostatin is termed a negative growth regulator. Explain themeaning of this term, and describe the consequences of genemutations that cause myostatin to be nonfunctional.True or false 1. Cytochrome p450 is considered to be the “universal oxygenase” 2. In alzheimer’s and Parkinson’s diseases, there is hyperphosphorylation of tau that leads to the intracellular accumulation of tau in the form of neurofibrillary tangles.
- With explain fastIn studies trying to understand the regulation of hormone-sensitive adenylatecyclase, it was discovered that non-hydrolyzable GTP analogs and cholera toxin (that inhibits theGTPase activity of Gs ) were able to activate the enzyme in a sustained (irreversible) profile, thereforeindicating that GTP hydrolysis represents a deactivation (turn-off) regulatory step.a) Will these analogs or toxin have any effect on adenylate cyclase activity in the absenceof any added hormone?b) If you add an factor that increases the rate of GTPase hydrolysis of the Gs protein, willthis activate or inhibit the observed downstream effect upon addition of the hormone (this is in theabsence of GTP analogs or toxin). Explain your answer.Utilizing Bentham's "Felicific Calculus" step-by-step, give a justification in practicing proper use of facemasks outdoors as a health protocol during this time of COVID-19.