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- In a P450 cycle, as shown in figure, ferrodoxin and ferrodoxin reductase are needed to form Fe (III) to Fe (III)-OOH. But why the peroxide shunt are also able to complete this process independent of Fd system (ferrodoxin and ferrodoxin reductase...)?Compare and contrast cytochrome p450 (CYP) and flavin- containing monooxygenase (FMO)Describe the activities of the cytochrome P450
- A hydrophilic drug A.Has a high reabsorption in renal tubules B.Has a low ability to penetraye the cell membrane C.Can cross the blood brain barrier easily D.Can bind to intracellular receptors. 2.The phase 1 reaction most often performed by mixed function CYP450 hepatic microsomal enzyme is A.Glucuronidation B.Oxidation C.Reduction D.Acetylation 3.CYP1A2 is involved in the metabolizing of several clinically important xenobiotics such as A.Caffeine B.Morphine C.Aspirin D.Alcohol 4.Drug metabolism,the drug.......undergoes phase 2(acetylation)before undergoing phase 1 (hydrolysis) metabolic reactions A Aspirin B.Codeine C.Isoniazid D.Diazepam E.Phenytoin 5.Which of the following statements is/are true regarding the oxidation of aromatic rings A.Electron donating substituents promote oxidationat the meta position B.Electron withdrawing substituents promote oxidation at the meta position C.All aromatic rings in a molecule are hydroxylated D Monosubstituted aromatic rings can be…What are consequences of the metabolism of ethanol by the cytochrome P450 system and also its induction by ethanol?Which of the following enzymes is involved in the oxidation reaction (drug metabolism)? Select one: Lactate dehydrogenase Esterase Cytochrome P450 Chymotrypsin
- Which of the following best describes the action of cytochrome c oxidase? a. Cytochrome c oxidase combines water and oxygen to produce hydrogen peroxide. b. Cytochrome c oxidase transports electrons out of the respiratory reaction. c. Cytochrome c oxidase enables oxygen to accept electrons at the end of the electron transport respiratory chain. d. Cytochrome c oxidase converts hydrogen peroxide into water and oxygen. e. Cytochrome c oxidase reduces thiosulfate anion to hydrogen sulfide.FAD is reduced in which of the following reactions/transformations in the Krebs cycle? a. Succiny| CoA to succinate b. Isocitrate to oxaloacetate c. Fumarate to malate d. Succinate to fumarateHow many C02 molecules are produced from the complete oxidation of stearic acid through catabolic pathways? A. 14 B. 16 C. 18 D. 20