Question
Asked Jun 20, 2019

Which of the following would not increase Cardiac Output?

A. increase blood epinephrine concentration

B. Increase Atrial Preload

C. Increase Cardiac sarcoplasmic calcium concentration

D. Increase Arterial Afterload

 

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Step 1

The amount of blood pumped by the ventricles in 1 minute is measured in terms of cardiac output (CO). It is calculated by taking the product of stroke volume and the heart rate. Here, the volume of blood pumped by both the ventricles is termed as stroke volume. While contractions of the heart in one minute is termed as the heart rate. Mathematically, it is written as,

Cardiac output (CO) = Stroke volume x Heart rate
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Cardiac output (CO) = Stroke volume x Heart rate

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Step 2

The explanation for the correct answer:

 

D.Increase in arterial afterload. As the afterload increases, the stroke volume decreases. This is because increased afterload causes the velocity of fiber shortening decreases. This causes a decrease in the ejection of blood from the ventricle, resulting in an increase in end-systolic volume in ventricles. This results in decreased cardiac output. Hence, this option is correct.

Step 3

The explanation for the incorrect answers:

A. The high concentration of blood epinephrine. High epinephrine concentration increases the heart rate. This further results in increased cardiac output. High cardiac output transports more oxygen to the muscles, preparing the body to react in the stress situation. Hence, this option is incorrect.

B. Increase in arterial preload. The higher end-diastolic volume means there is high preload. When the preload increase, left ventricle expels more blood, lead...

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