With regard to fluid movement between body fluid compartments, what effect does oral/parenteral administration of a hypotonic NaCl solution (0.45% NaCl, 145 mOsm/kg) have on the volume & osmolality of the extracellular fluid compartment (ECF), and on the volume & osmolality of the intracellular fluid compartment (ICF)? Clearly explain

With regard to fluid movement between body fluid compartments, what effect does oral/parenteral administration of a hypotonic NaCl solution (0.45% NaCl, 145 mOsm/kg) have on the volume & osmolality of the extracellular fluid compartment (ECF), and on the volume & osmolality of the intracellular fluid compartment (ICF)? Clearly explain

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter15: Fluid And Acid-base Balance

Section: Chapter Questions

Problem 3UC

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One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?
Gout is caused by an error in metabolism that leads to abuildup of uric acid in body fluids, which is deposited as slightlysoluble sodium urate (C₅H₃N₄O₃Na) in the joints. If the extra-cellular [Na⁺] is 0.15 Mand the solubility of sodium urate is0.085 g/100. mL, what is the minimum urate ion concentration(abbreviated [Ur⁻]) that will cause a deposit of sodium urate?
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