Yarrowia lipolytica(Yl) is a non-conventional yeast that diverged from baker’s yeast, Saccharomyces cerevisiae(Sc), early in evolutionary history. The regulation of glycolytic enzymes in Yl differs from that of Sc. The data below pertain to regulation of phosphofructokinase 1 (PFK). Data for Yl is shown with black circles and data for Sc is shown with white circles. Imagine that the genes for phosphofructose kinase 2 and fructose 2,6-bisphosphatase were deleted in each species. Which species would you expect to have greater metabolic disruption and why?
Yarrowia lipolytica(Yl) is a non-conventional yeast that diverged from baker’s yeast, Saccharomyces cerevisiae(Sc), early in evolutionary history. The regulation of glycolytic enzymes in Yl differs from that of Sc. The data below pertain to regulation of phosphofructokinase 1 (PFK). Data for Yl is shown with black circles and data for Sc is shown with white circles. Imagine that the genes for phosphofructose kinase 2 and fructose 2,6-bisphosphatase were deleted in each species. Which species would you expect to have greater metabolic disruption and why?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Yarrowia lipolytica(Yl) is a non-conventional yeast that diverged from baker’s yeast, Saccharomyces cerevisiae(Sc), early in evolutionary history. The regulation of glycolytic enzymes in Yl differs from that of Sc. The data below pertain to regulation of phosphofructokinase 1 (PFK). Data for Yl is shown with black circles and data for Sc is shown with white circles.
Imagine that the genes for phosphofructose kinase 2 and fructose 2,6-bisphosphatase were deleted in each species. Which species would you expect to have greater
Transcribed Image Text:1.0
1.0
0.8
0.8
ScPfk
0.6
0.6
ScPfk
0.4
0.4
0.2
0.2
2 4
6
8
10
%23
50 100
P-enolpyruvate (mM)
10 15 20
Fructose-2,6-P2 (µM)
Relative activity (v V-1)
Relative activity (v V-1)
Transcribed Image Text:YIPFK
1.0
0.8
0.6
ScPfk
0.4
0.2
%23
6 8 10
Fructose-6-P (mM)
1 2 3 4 5
Relative activity (v V-1)
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