You are head of a pharmaceutical R&D firm. Research has brought to you two drugs for the treatment of a disease. The major difference between the drugs is that one is significantly metabolized by two CYP P450 enzymes while the other is metabolized by only one CYP enzyme. Based on this data decide which drug to take to clinical trials (a $100,000,000 decision) and defend your choice. List three questions you might ask your researchers. Explain why they are important criteria for making a decision.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 46SST
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FOR ACADEMIC PURPOSES ONLY - NOT FOR CLINICAL USE
Test Details
Gene
Genotype
Phenotype
Alleles Tested
CYP2C19
*2/*7
Poor Metabolizer
*2, *3, *4, *48, *5, *6, *7, *8, *9, *17
CYP2D6
*1/4
Intermediate Metabolizer
*2, *3, *4, *4M, "6, *7, *8, *9, *10, *12, *14A, *148, *17, *29,
*35, *41
CYP3AS
*3/*3
Poor Metabolizer
*1D, *2, *3, *38, *3C, "6, *7, "8, *9
CYP3A4
*1/*1
Normal Metabolizer
*18, *2, *3, *12, *17, *22
VKORCI
-1639G>A G/A
Intermediate Warfarin Sensitivity
-1639G>A
*2, *3
*2, *3, *4, *5, "6, *11
CYP4F2
*1/3
Decreased Function
CYP2C9
*1/*1
Normal Metabolizer
CYP2B6
*1/*1
Normal Metabolizer
*6, *9
Normal Metabolizer - Higher
Inducibility
CYPIA2
*1F/"1F
*1C, *1D, *1F, *1K, *1L, *1V, *1W
SLCOIB1
521T>CT/T
Normal Function
521T>C, 388A>G
CFTR
F508del/RS53X
Negative
Numerous
DPYD
*1/*1
Normal Metabolizer
Numerous
ТРМТ
*1/*3A
*1/1
Intermediate Metabolizer
Normal Metabolizer
*2, *3A, *38, *3C, *4
*2, *3, *4, *5, "6, *7, *8, *9
NUDT15
UGTIAI
*1/*36
Normal Metabolizer
*6, *27, *28, *36, *37, *60, "80
G6PD Bangkok or Bangkok/
Bangkok
Deficient with CNSHA
Numerous
Additional Test Results (added to this original report)
HLA-A*31:01 negative/negative Negative
HLA-B'15:02 negative/negative Negative
HLA-B'57:01 negative/negative Negative
HLA-B'58.01 negative/negative Negative
You are head of a pharmaceutical R&D firm. Research has brought to you two drugs for the
treatment of a disease. The major difference between the drugs is that one is significantly
metabolized by two CYP P450 enzymes while the other is metabolized by only one CYP enzyme.
Based on this data decide which drug to take to clinical trials (a $100,000,000 decision) and defend
your choice. List three questions you might ask your researchers. Explain why they are important
criteria for making a decision.
Transcribed Image Text:FOR ACADEMIC PURPOSES ONLY - NOT FOR CLINICAL USE Test Details Gene Genotype Phenotype Alleles Tested CYP2C19 *2/*7 Poor Metabolizer *2, *3, *4, *48, *5, *6, *7, *8, *9, *17 CYP2D6 *1/4 Intermediate Metabolizer *2, *3, *4, *4M, "6, *7, *8, *9, *10, *12, *14A, *148, *17, *29, *35, *41 CYP3AS *3/*3 Poor Metabolizer *1D, *2, *3, *38, *3C, "6, *7, "8, *9 CYP3A4 *1/*1 Normal Metabolizer *18, *2, *3, *12, *17, *22 VKORCI -1639G>A G/A Intermediate Warfarin Sensitivity -1639G>A *2, *3 *2, *3, *4, *5, "6, *11 CYP4F2 *1/3 Decreased Function CYP2C9 *1/*1 Normal Metabolizer CYP2B6 *1/*1 Normal Metabolizer *6, *9 Normal Metabolizer - Higher Inducibility CYPIA2 *1F/"1F *1C, *1D, *1F, *1K, *1L, *1V, *1W SLCOIB1 521T>CT/T Normal Function 521T>C, 388A>G CFTR F508del/RS53X Negative Numerous DPYD *1/*1 Normal Metabolizer Numerous ТРМТ *1/*3A *1/1 Intermediate Metabolizer Normal Metabolizer *2, *3A, *38, *3C, *4 *2, *3, *4, *5, "6, *7, *8, *9 NUDT15 UGTIAI *1/*36 Normal Metabolizer *6, *27, *28, *36, *37, *60, "80 G6PD Bangkok or Bangkok/ Bangkok Deficient with CNSHA Numerous Additional Test Results (added to this original report) HLA-A*31:01 negative/negative Negative HLA-B'15:02 negative/negative Negative HLA-B'57:01 negative/negative Negative HLA-B'58.01 negative/negative Negative You are head of a pharmaceutical R&D firm. Research has brought to you two drugs for the treatment of a disease. The major difference between the drugs is that one is significantly metabolized by two CYP P450 enzymes while the other is metabolized by only one CYP enzyme. Based on this data decide which drug to take to clinical trials (a $100,000,000 decision) and defend your choice. List three questions you might ask your researchers. Explain why they are important criteria for making a decision.
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