You come across four polynucleotide strands. The first is an original RNA strand that codes for a protein; the others are similar to the original RNA strand, except that each displays a point mutation. The point mutations are shown in red. 5' - AUG-UGC-AUU-CCU-GCA-UAA - 3' 5 - AUG-UGA-AUU-CCU-GCA-UAA - 3' 5' - AUG-UGC-AUU-CCC-GCA-UAA - 3' 5' - AUG-UGC-GUU-CCU-GCA-UAA - 3' Original RNA: Mutant RNA 1: Mutant RNA 2: Mutant RNA 3: 1. Based on how they will affect the protein product, identify the type of point mutation (missense, nonsense, silent, or frameshift) present in the Mutants 1, 2, and 3. 2. State which of the point mutations (for the three specific mutant RNAS in this question) would have the greatest impact on the protein produced, and explain/justify your choice.
You come across four polynucleotide strands. The first is an original RNA strand that codes for a protein; the others are similar to the original RNA strand, except that each displays a point mutation. The point mutations are shown in red. 5' - AUG-UGC-AUU-CCU-GCA-UAA - 3' 5 - AUG-UGA-AUU-CCU-GCA-UAA - 3' 5' - AUG-UGC-AUU-CCC-GCA-UAA - 3' 5' - AUG-UGC-GUU-CCU-GCA-UAA - 3' Original RNA: Mutant RNA 1: Mutant RNA 2: Mutant RNA 3: 1. Based on how they will affect the protein product, identify the type of point mutation (missense, nonsense, silent, or frameshift) present in the Mutants 1, 2, and 3. 2. State which of the point mutations (for the three specific mutant RNAS in this question) would have the greatest impact on the protein produced, and explain/justify your choice.
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
Problem 3CRQ
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Concept explainers
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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Question
![Second letter
UUU
UUC
UUA
UUG.
UCU
UCC
UCA
UCG
UAU
Tyr
UAC.
Ser
UAA Skp UGIA Stop
UGU
UGC.
Phe
Cys
Leu
UAG Sop UGG Trp
CGU
CGC
Arg
CGA
CCU
CAU
CUU
CUC
CUA
CUG
His
CAC
CAA
CAG Gin
CCC
Pro
CCA
Leu
CCG
CGG
ACU
AAUA
AGU
]Ser
AUU
Asn
AAC
AGC
AGA LArg
AGG.
AUC Be
ACC
ACA
Thr
AAA
AUA
AUG Met ACG
MGys
GUU
GUC
Val
GUA
GCU
GCC
GCA
GCG
Ala
GAA
Glu
GAG
GAU
GAC Asp
GGU
GGC
Gly
GGA
GGG
GUG
You come across four polynucleotide strands. The first is an original RNA strand that codes for a
protein; the others are similar to the original RNA strand, except that each displays a point mutation.
The point mutations are shown in red.
5' - AUG-UGC-AUU-CCU-GCA-UAA - 3'
5' - AUG-UGA-AUU-CCU-GCA-UAA - 3'
5' - AUG-UGC-AUU-CCC-GCA-UAA - 3'
5' - AUG-UGC-GUU-CCU-GCA-UAA - 3'
Original RNA:
Mutant RNA 1:
Mutant RNA 2:
Mutant RNA 3:
1. Based on how they will affect the protein product, identify the type of point mutation (missense,
nonsense, silent, or frameshift) present in the Mutants 1, 2, and 3.
2. State which of the point mutations (for the three specific mutant RNAS in this question) would
have the greatest impact on the protein produced, and explain/justify your choice.
First letter
Third letter](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4c41347e-3655-4f1b-a7f6-8cc7c85b277c%2F3142c3ec-3a1e-4bc4-8c49-5c9371068692%2Fdt5ujm_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Second letter
UUU
UUC
UUA
UUG.
UCU
UCC
UCA
UCG
UAU
Tyr
UAC.
Ser
UAA Skp UGIA Stop
UGU
UGC.
Phe
Cys
Leu
UAG Sop UGG Trp
CGU
CGC
Arg
CGA
CCU
CAU
CUU
CUC
CUA
CUG
His
CAC
CAA
CAG Gin
CCC
Pro
CCA
Leu
CCG
CGG
ACU
AAUA
AGU
]Ser
AUU
Asn
AAC
AGC
AGA LArg
AGG.
AUC Be
ACC
ACA
Thr
AAA
AUA
AUG Met ACG
MGys
GUU
GUC
Val
GUA
GCU
GCC
GCA
GCG
Ala
GAA
Glu
GAG
GAU
GAC Asp
GGU
GGC
Gly
GGA
GGG
GUG
You come across four polynucleotide strands. The first is an original RNA strand that codes for a
protein; the others are similar to the original RNA strand, except that each displays a point mutation.
The point mutations are shown in red.
5' - AUG-UGC-AUU-CCU-GCA-UAA - 3'
5' - AUG-UGA-AUU-CCU-GCA-UAA - 3'
5' - AUG-UGC-AUU-CCC-GCA-UAA - 3'
5' - AUG-UGC-GUU-CCU-GCA-UAA - 3'
Original RNA:
Mutant RNA 1:
Mutant RNA 2:
Mutant RNA 3:
1. Based on how they will affect the protein product, identify the type of point mutation (missense,
nonsense, silent, or frameshift) present in the Mutants 1, 2, and 3.
2. State which of the point mutations (for the three specific mutant RNAS in this question) would
have the greatest impact on the protein produced, and explain/justify your choice.
First letter
Third letter
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