You've engineered a mutant cell where the FADD adapter was truncated. The mutant FADD only contains the Death Domain, and lacks the Death Effector Domain. What is the most likely phenotypic outcome for this mutant cell when presented with the Fas ligand?

Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
Section: Chapter Questions
Problem 19RQ: A scientist notices that a cancer cell line fails to die when he adds an inducer of apoptosis to his...
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You've engineered a mutant cell where the FADD adapter was truncated. The mutant
FADD only contains the Death Domain, and lacks the Death Effector Domain. What
is the most likely phenotypic outcome for this mutant cell when presented with the
Fas ligand?
20
E
O The Fas/FasL oligomer is formed, but apoptosis is blocked
O The Fas/FasL oligomer is formed, and apoptosis is hyperactivated
O The Fas/FasL oligomer is not formed, and apoptosis is blocked
O The Fas/FasL oligomer is not formed, but apoptosis is hyperactivated
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Transcribed Image Text:# 3 You've engineered a mutant cell where the FADD adapter was truncated. The mutant FADD only contains the Death Domain, and lacks the Death Effector Domain. What is the most likely phenotypic outcome for this mutant cell when presented with the Fas ligand? 20 E O The Fas/FasL oligomer is formed, but apoptosis is blocked O The Fas/FasL oligomer is formed, and apoptosis is hyperactivated O The Fas/FasL oligomer is not formed, and apoptosis is blocked O The Fas/FasL oligomer is not formed, but apoptosis is hyperactivated F3 $ 4 DOD 000 R F4 % 5 F5 T BARAT 6 tv @ MacBook Air F6 Y & 7 F7 U * ➤11 8 F8 · 9 F9
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