Ciclosporin

Psoriasis: The Genetic and Immune-Mediated Implications Psoriasis is a common chronic autoimmune disorder that is characterized as having an immune-mediated inflammatory pathology which presents with skin lesions that vary in severity. Affecting nearly 3% of the world population (Jadali & Eslami 2014) the cause of psoriasis in not fully understood, but there is considerable evidence that points to genetic, environmental, and immunological factors that influence the disease.

Abstract Interactions between multiple drug substances, taken in combination or simultaneously, may yield excessive risk of adverse effect. However, this increase risk is not uniform for all combinations. Some combinations may show a constant risk pattern. Collections of individual reporting of an adverse event related to adverse drug reactions have proven to be very useful. A mixture model approach is applied to AERS (adverse effect record system) data to differentiate drug combinations following