Synthesis Of Acetaminophen Essay

isolate pure acetaminophen from p-aminophenol using a synthesis reaction. Synthesis still remains an important tool for scientists conducting chemical reactions. Most synthesis relies on a long process that involves multiple chemicals reactions. In the synthesis of Acetaminophen, one reaction is performed and a four step process is used, Scheme 1. Multiple techniques was used to achieve this goal. Scheme 1. The chemical equation that expressed how p-aminophenol is converted into acetaminophen. During

Synthesis of Acetaminophen Lab Report Bijal Patel, 20467049 Partner: Poojan Parikh T.A.’s: Long Pu CHEM 123L, Section: 006, Rm: ESC 149 Tuesday February 4, 2013, 2:30pm-5:20pm Experiment Done: Tuesday January 22, 2013 Introduction Acetaminophen was first introduced in 1955 (Richman, 2004). It is an over-the-counter drug that relieves pain and reduced fevers. Acetaminophen is considered an alternate to aspirin since it does not irritate the stomach (Richman, 2004). It also has very

349mg of solid acetaminophen was weighed and placed into a 5mL conical vial with a triangular spin vane, point facing downward. Next, 2.6mL of 1M NaOH were added to the same vial. An air condenser was attached to the vial; both were clamped to a stability rod above a hot plate. An aluminum block was placed onto the hot plate stabilize the vial. A small thermometer was placed in the same aluminum block. The solution was heated gently and simultaneously stirred for 10 minutes until all solid was dissolved

o prepare Acetaminophen a water bath was set up in a 400-mL beaker and then placed onto a hotplate where it reached a boil. During the time it took for the water bath to boil, a 125-mL Erlenmeyer flask was obtained. P-aminophenol (1.5g) was weighed and then placed inside the Erlenmeyer flask. Deionized water (25 mL) was added to the flask followed by 35 drops of concentrated phosphoric acid. An additional 15 drops were added to the solution, since the initial 20 drops of concentrated phosphoric

The purpose of the experiment was to extract acetaminophen from p-aminophenol using a synthesis reaction technique, as shown in Scheme 2. Acetic anhydride was poured into p-aminophenol and used reflux to break down chemical bonds. This was one step process to perform the synthesis. Information about the chemical reaction was provided from the lab manual (Arizona State University, 2017). Scheme 2. The N-H bond in p-aminophenol and one of the C-O bond in acetic acid is severed to form the product

Acetaminophen is an non-opioid analgesic while ibuprofen is a non-steroidal anti-inflammatory drug (NSAIDs). Acetaminophen is an equipotent inhibitor of cyclooxygenase 1 and 2, while ibuprofen is more selective for cyclooxygenase 1 than 2. Although the mechanism of action of acetaminophen is unclear, it is generally believed to work the same was as ibuprofen. Ibuprofen and acetaminophen produce therapeutic effects by reversibly inhibiting cyclooxygenase and thus blocking the synthesis of proinflammatory

ABSTRACT: The objective of this lab is to synthesize acetaminophen from p-aminophenol. The techniques used to do so, consist of: reflux with heat to allow reaction to occur at a reasonable time period, extraction and filtration to isolate the desired product, and characterization of the product by analyzing IR spectras and melting points. Acetaminophen considered synthesized, primarily due to the IR spectrum exhibiting all the bond vibrations is the amide group. The percent yield of 124.6% imply

vial attached to an air condenser to synthesize crude acetaminophen, resulting in 0.097 grams (47.48% yield). The crude acetaminophen was then recrystallized in a solvent of water and methanol over heat resulting in 0.082 grams (39.61% yield) of pure acetaminophen. Melting points of both crude and pure acetaminophen were taken, and found to be 165.9 - 170.9°C and 168.2 - 171.5°C, respectively. The literature melting point of acetaminophen is 169.5 – 171.0°C, indicating that our final product was

however, p-Phenetidine and Acetaminophen are actually metabolites of Phenacetin. This explains why some of the side effects of Phenacetin are so severe. P-Phenetidine has been found to cause methaemoglobinaemia, a serious side effect where abnormal amounts of methaemoglobin, a type of hemoglobin, are produced. This protein helps carry oxygen to every part of the body, but is unable to distribute the oxygen effectively, causing severe headaches and cyanosis. Acetaminophen, since it is processed in

Experiment 6A: Williamson Ether Synthesis of Phenacetin This lab synthesized the organic compound phenacetin by performing a Williamson Ether Synthesis on acetaminophen. In this reaction acetaminophen’s hydroxyl hydrogen is substituted for an ethyl group to make phenacetin. An alcohol is being turned into an ester; where, the hydrogen of the hydroxyl group is removed by a carbonate anion and the remaining phenoxide anion backside attacks an ethyl iodine to obtain an ethyl group. If the reaction