Thrombocytopenia

A more rare cause of thrombocytopenia in pregnancy is the immune thrombocytopenic purpura (ITP), an autoimmune disorder characterized by the anti-platelet glycoprotein antibodies that stimulate the platelet destruction in the spleen.6 There are two types of ITP: the acute form that is common in children, is associated with viral infections and is self-limiting and the chronic form which predominantly affects women. The diagnosis is clinical. Thrombocytopenia in ITP is generally moderate but with

Autoimmune Thrombocytopenia (ITP) is an immune system disorder where the reaction of the immune system attacks itself causing a low platelet count, placing those affected at risk for severe hemorrhage. Autoimmune Thrombocytopenia (ITP) formally known as idiopathic thrombocytopenia purpura (ITP), is now defined as an immunological disorder where the body attacks its self and destroys platelets (McCare 2011). ITP a disorder defined by a low platelet count in which platelet productions are both impaired

Amegakaryocytic thrombocytopenia is a rare complication of Systemic Lupus Erythematosus (SLE) with occasional reports of successful treatment with Cyclosporine, Rituximab, and Eltrombopag. Both humoral and T-cell mediated mechanisms have been implicated in impaired thrombopoiesis with the setting of lupus. We report glucocorticoid refractory amegakaryocytic thrombocytopenia successfully treated with Azathioprine (AZA) in a middle-aged lady with lupus. To our knowledge, this is the first reported

In this lecture prof. Wuhrer discussed the relevance of using changes in glycosylation patterns as a biomarker in autoimmune diseases and cancer with use of mass spectrometry. Glycosylation is the covalent addition of glycans (carbohydrate) to another molecule, which contains a hydroxyl group or other functional group. Other molecule can be proteins, lipids or other bio molecules. This process is a form of co-translational and post-translational modification, which occurs in endoplasmic reticulum

familial or sporadic, that affect both children and adults, making it difficult to diagnose (Noris & Remuzzi, 2010; NORD, 2016). Atypical Hemolytic Uremic Syndrome is distinguished by three main manifestations: hemolytic anemia (destruction of RBC), thrombocytopenia (low platelets), and uremia NORD, 2016; Loirat & Fremeaux-Bacci, 2011; Biermann, 2017; Kaplan,

occur: easy bruising of the skin, petechiae, blood in urine, black tarry stools, nosebleeds, bleeding from the gums, increase in vaginal bleeding, and new onset of painful joints. (Williams, L. S., & Hopper, P. D. (2015, p. 573-574). Idiopathic thrombocytopenia purpura (ITP) is clinically diagnosed through a thorough medical history including a physical examination, complete blood count (CBC), and peripheral blood smear examination. (Blackwell, J., & Goolsby, M. J. (2003)). Upon examination of laboratory

Subjects The study subject was divided into 4 groups. Group I: 21 patients with hepatic schistosomiasis (12 male and 9 females). Group II: 18 patients with HCV infection (10 male and 8 females). Group III: 23 patients with concomitant hepatic schistosomiasis and HCV infections (13 male and 10 females). Group IV: 20 healthy individuals as controls (12 male and 8 females). Full history taking including contact with water canal water were collected from the study subject Abdominal ultrasound Ultrasonography

October 17, 2009, my world changed. My little brother, Brennan, was diagnosed with idiopathic thrombocytopenia purpura, in short known as ITP. Normally, platelets are made in bone marrow and make their way through the blood stream and filtered out by the spleen. In Brennan’s case, his platelets are destroyed by his body causing his platelet count to drop to life threatening levels. Brennan’s platelet count from 2009, to today in 2016, has never gotten higher than 20,000; which means that he is at

My mom was diagnosed with pancreatic cancer stage IV last July. “I could believe what was happening to me, at the age of 44 I considered myself a healthy person, I was never sick, I never smoked, I was highly active and had a healthy diet. I couldn't find a possible explanation that justified this illness.” she said. It was really though for my family, we couldn't even say the word “cancer” for a few months. We became angry because we thought that my mom didn’t deserved that. The doctors were confident

Adverse drug reaction : Case reports on methotrexate toxicity varied presentation. Introduction : In 1949, Sidney Farber, M.D., a pathologist and a clinician formed a theory that folic acid is required for the growth of cancer cells and methotrexate being a folate antagonist can be used to counter it. Since then it has been used in dermatology, gynaecology, rheumatology and cancers. Methotrexate formerly known as amethopterin is an antimetaboliteand dermatologically it is FDA approved mainly