Tissue plasminogen activator

Cancer is the second leading cause of death with 14 million new cases and 8.2 million cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies, neoplastic diseases are still a major therapeutic challenge notably because of intra- and inter-malignant tumor heterogeneity and adaptation/escape of malignant cells to/from treatment. New targeted therapies need to be developed to improve our medical arsenal and counter-act cancer progression. Human kallikrein-related peptidases

paratrooper, that increase the risk of sustaining a TBI. (Langlois, JA, 2006) Contusions are classified as a bruise or bleeding on the brain caused by impact. Another type of traumatic brain injury is diffuse axonal injury, which causes tearing of the nerve tissue or blood vessels when the brain is shook in the

know how to treat heart disease instead of putting the patient in a room and giving him pain relievers and “lidocaine, which doctors believed would prevent dangerous irregular heartbeats” • Doctors treat a heart attack with drugs like tissue plasminogen activators, which are proteins involved in the breakdown of blood clots. • Tiny tubes prop open blocked blood vessels. • A host of new drugs like Simvastatin, Lipitor, Mevacor and Crestor routinely slow the advance of atherosclerosis, or the hardening

As a medical scribe in an emergency department, I constantly work in a fast paced environment where I learn something new everyday. One of the first things I learned is that some days are more challenging than others. For example, approximately eight hours into my third day of training, an urgent overhead page called out, “Code Heart Emergency Department Room 5.” The doctor I was working with sprinted to Room 5 with me rushing in his wake, trying to keep up. I squeezed my way into the packed room

final maturation stage, the collagen is remodeled over time. When the body is inflicted with a penetrating wound, vessels and tissue fibers are ripped and broken. The area is then filled with leaking blood from the surrounding vessels and the outermost blood flow begins to form a scab. The surrounding vessels at that time constrict to minimize the blood leakage in a process known as vasoconstriction. The first step of the body is to clot the blood and achieve hemostasis, or blood clotting to impede

of the endothelium is responsible for thrombotic state (Kyrle, 2009). Endothelial injury is the physical loss of endothelium leading to exposure of subendothelial extra-cellular matrix, adhesion of platelets, release of tissue factor, depletion of PGI2 and plasminogen activators (Kumar, 2010). Abnormal blood flow refers to turbulence that causes endothelial injury, which is a major influence

Geneticists continue to look for ways to genetically alter genes and transformation to better the lives of other people. In this experiment the goal was to understand the transformation process and how genetically engineering bacteria could possibly be useful. The transformation process involved 5 steps: pre-incubation, incubation, heat chock, recovery and growth, and selection. Four different plates were used to analyze the effects of the transformation. The plates were as follows: plate 1 contained

In recent decades, improved socioeconomic conditions have led to the expansion of the overweight population worldwide. Obesity is well known to be a risk factor for the development of diabetes mellitus, hypertension and coronary artery disease [1] and is also thought to increase the risk of perioperative morbidity and mortality with cardiac surgery, as evidenced by its inclusion into the Parsonnet system for the stratification of risk for perioperative death [2]. The analysis of the National Cardiac

The oral mucosa is a specialized tissue lining the oral cavity and consists of the following components: (1) the masticatory mucosa, which lines the gingiva and the hard palate; (2) the specialized mucosa covering the dorsum of the tongue; and (3) the lining mucosa which covers the reminder of the oral cavity [201, 202]. The gingiva is considered an adaptation of the oral masticatory mucosa covering the alveolar bone and surrounding the cervical portions of teeth. The gingiva protects the roots of

An intricate link between inflammation and coagulation exists within the body (Neligan, 2006). When a pathogen is present in the bloodstream or when tissue injury occurs, an inflammatory response occurs. The response causes a stimulation of the immune system to produce interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα) (Neligan, 2006). These cytokines are the main catalysts