Satisfactory Essays
1,2-Dipalmitoyl-sn-glycerol (1,2-DPG) is an analog of the protein kinase C (PKC)-activating second messenger diacylglycerol [1].
Diacylglycerol acts as a second messenger signaling lipid. Diacylglycerol is generated through the hydrolysis of the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) by the enzyme phospholipase C (PLC). Production of DAG facilitates translocation of PKC from the cytosol to the plasma membrane [2].
1,2-Dipalmitoyl-sn-glycerol (1,2-DPG) was a weak activator of PKC. 1,2-Dipalmitoyl-sn-glycerol at 25 µM activated 15% of PKC [1].
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