pathogeneses [16]. Various researchers have reported the effect of activated LXR on melanogenesis [7-10]. The aim of this study is to evaluate the possible hypothesized role of liver x receptor alpha (LXR-α) in in the pathogenesis of vitiligo. In the present study the expression of LXR-α was positive in epidermis and dermial adnexa of lesional, perilesional, and control
LXR-α and LXR-β are expressed in cultured human keratinocytes and throughout all layers of the human epidermis.14 Scarce number of studies has discussed the effect of activated LXR on melanogenesis in Vitiligo. Kumar and his associates (2010) demonstrated that LXR-α was also expressed in melanocytes and it was up-regulated in the melanocytes from perilesional skin of vitiligo patients in comparison to non lesional skin, suggesting that LXR-α might be
Graves’ Disease is identified as an autoimmune disorder that directly affects the thyroid gland. Characterized as the most common cause of hyperthyroidism, Graves’ Disease encompasses an overactive, enlarged thyroid gland, which produces an excess of thyroid hormones [1]. Approximately 3% of the United States population is affected by Graves’ Disease and 60-80% of patients affected with Graves’ disease are diagnosed with hyperthyroidism [2]. The approximate female to male ratio is 5/1, with majority