A Research Study On Vitiligo Pathogenesis

4. Discussion Vitiligo is an acquired depigmentation disorder of skin and hair. It is a cosmetically disfiguring disease caused due to melanocytes destruction [Moretti et al., 2002], however, the pathogenesis of such disease is still conflicting. Many previous studies tried to explain the pathogenesis according to many points of view, they showed that it could either be an autoimmune mechanism, a neural dysfunction, metabolic mechanism, or genetic causes [Moretti et al., 2002, Zhang et al,2005, Yazici et al., 2006]. In this study, we decided to assess the genetic factor in vitiligo pathogenesis. Our study detected a non-significant association between IFN-γ +874A/T or +2109A/G gene polymorphism and vitiligo susceptibility. In line with our finding Dwivedi, et al,2013 couldn 't consider IFN- γ +874 T/A polymorphism as a genetic risk factor for generalized vitiligo. Also, an Iranian study, couldn’t confirm a relation between IFN- γ +874 T/A gene polymorphism and vitiligo risk [Namian et al., 2009]. When we studied the different haplotype frequencies of INF-γ (+874A/T) and INF-γ (+2109A/G) polymorphisms in vitiligo patients and control distributions, we observed a significant elevation of the haplotype TA in vitiligo patients when compared with control group (P < 0.03), this indicated increased risk of vitiligo with this haplotype. To the best of our knowledge, no previous studies were done to assess IFN-γ +2109A/G gene polymorphism in relation to vitiligo and no