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A Summary Of Osteoarthritis

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Osteoarthritis is an ailment of complex etiology that results in loss of normal function due to the failure of joint articular cartilage. Therefore, it can be defined as a sickness of the cartilage where the kind of tissue with compressive properties and viscoelasticity reported by its extracellular matrix, comprised mostly of proteoglycans and type II collagen (Boissonnault, 2011 p90). As per pathophysiology of osteoarthritis manifested by biochemical, morphological, and molecular changes in both cells and matrix which lead to becoming weaker that also leads to sclerosis, ulceration, fibrillation, damage of joint articular cartilage, eburnation of subchondral osteophyte bone and subchondral cysts. Under typical situations, this matrix is …show more content…

These are obtainable by prescription or over-the-counter like NSAIDs, including naproxen sodium (Aleve and others), and ibuprofen (Advil, Motrin IB, others) when taken at the recommended doses, can get rid of osteoarthritis pain. Heavy-duty NSAIDs, which is available by prescription, may reduce inflammation along with relieving pain. Some antidepressants, such as duloxetine, will help relieve pain. Opioids can be administered to relieve severe pain, but it can be addictive. There are are some powerful anti-inflammatory medicines like corticosteroids that are administered orally or by injection at a doctor’s office directly to the joint. Found naturally in the joint fluid is Hyaluronic acid that serves as a shock absorber and lubricant. The acid can be commercially manufactured and seems to alleviate pain quickly in people diagnosed with OA. Acetaminophen is the common drug of choice, but topical capsaicin and glucosamine/chondroitin also considered. If these drugs are not effective, NSAIDs and cyclooxygenase (COX)-2 inhibitors are tried (Ciccone, 2016 p219). Whereas there is confirmation suggesting that NSAIDs are better than acetaminophen in alleviating pain in patients with OA. The range of controlling the outcome cannot assert because the median trial length was merely six weeks. Because of this, further observations are required when creating the choice between taking NSAIDs or acetaminophen. However, in patients with moderate-to-severe levels of pain, NSAIDs seem to be the better choice than acetaminophen. (Kalunian,

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