Almost 8 million people are infected with hookworm (Freary et al), in severe cases it can result in death. On the contrary, epidemiological evidence suggests the hookworm may help with allergies and asthma. Two different scientific tests were performed to see if hookworms could help with symptoms of allergies and asthma. The first study was done to determine if hookworm infection would help airway responsiveness in a person who has allergies. The second study tested “to see the effects of experimental hookworm infection in asthma” (Freary et al). In comparison both the studies were trying to use hookworms as a treatment for issues with people’s immune systems. Contrastingly, the first study (based on allergies) had to be conducted first in …show more content…
The second experiment, dealing with asthma, used 32 people. Similarly to the first experiment it was randomized and was done double-blinded to make the results as accurate as possible. Half the participants received the placebo and the other half received the actual hookworm infection, just like the allergy experiment. For both, each of the recipients of the placebo and hookworm infection was watched closely for 16 weeks. The experiments had important requirements to the people to participate. For the first experiment the participants had to be at least 18 years of age and not pregnant or planning on being pregnant during the course of the study. The second experiment participants had to be also at least 18 and not pregnant. They also had to have a “physician’s diagnosis of asthma treated with daily inhaled corticosteroids of up to 1000 mcg beclometasone” (Freary et al). The experiment participants had follow-up visits and were required to fill out surveys and journal about their experiences during the tests.
In the experiments the scientists for each stage of devolvement tracked the spreading through different parts of the body. In the first experiment one of the items that the scientists were looking for was maximum fall (the lowest fall in PD and AMP). For the airway responsiveness the placebo group did not show much difference than the hookworm group. Although looking at the
The dependent variable is pulsation rates of L. variegatus before and after they were in the treatments. The standardized variable of this experiment would be the temperature of the surroundings of the L. variegatus, the three pulsation rates taken for each worm before and after the treatments, and also the amount of time each worm was kept in their respective treatments. The level of treatment for this experiment would be ten because of the six different concentration treatments of caffeine and nicotine along with the four household drugs. The sample size of the experiment differed from some treatments to other. For the three different concentrations of caffeine and nicotine, the sample size was 18 black worms each. The sample size of the control treatment of week 1 was 6 black worms. 12 black worms were used for the control of week 2, decaffeinated coffee and instant coffee. 11 black worms were used for the tea treatment and 15 were used for the tobacco treatment. There were three replications of the pulsation rate readings per worm before and after the treatment. With all this information we were able to get the results we got.
My predictions for the acceptance of the null hypothesis were very similar to the actual results with a few variations. My prediction of total arousal times for the first interval were the same however, on the second interval I had 60 total arousal times for the bats injected with the European P. destructans strand and the actual results had a total arousal of 80 bats injected with the European strand at interval
The experiment was conducted using six worms, where three were used for one treatment and the other three for a different treatment level. Initially, the worm was transferred to a parafilm slide containing some water and placed under a dissecting microscope. Application sticks were used to place the worm on the mark and an additional light was placed to observe. The focus was on the posterior end of the worm to obtain the basal pulsation rate. A timer was used to record the basal pulsation rate for 15 seconds, then the result was multiplied by 4 to get the number of beats per minute and this was repeated for two more trials. Same methods were used to measure the pulsation rate of two additional worms and the data were recorded.
The one downside to the trial is that each patient must consumer their allergenic foods every day. Initially, they must eat full services until their blood work and skin tests come back negative for the allergy. This can take from six months to three years, after which they are able to eat a much smaller daily amount. Because children did not react well to being forced to eat things they didn't want, many subsequent studies lost up to a third of their
Throughout this experiment a number of random and procedural errors were apparent; these errors could have affected the results of the experiment in a number of ways. One experimental error that occurred during the experiment was that some flies became stuck in the food source and died. The main cause of this was the fact that the fly vials were stood up (vertically) before the flies had fully recovered from the anaesthetic. This could be overcome in future experiments by ensuring that the vials are kept horizontal until all of the flies fully recover from the anaesthetic.
In the film, Foul Water, Fiery Serpent, former president, Jimmy Carter shows his process of eradicating Guinea Worm disease. With the help of Director Gary Strieker, Carter educates viewers on how the disease forms, how it has spread throughout countries, and how it will soon be defeated. When Guinea worm first surfaced, there were 3.5 million cases in 20 countries worldwide. With the help of Jimmy Carter, his campaign members, and many more, they have managed to drop these cases down to 3,190 by the year 2009. With some statistical facts at the end of the documentary, Guinea worm is likely to be the next disease in the history of mankind to be eradicated from the earth, right after smallpox. It was also the first parasitic disease to be eradicated, and the first disease to be eradicated without the use of vaccines or medicines. With this campaign, reported cases went from 4,136 in 2007, to 242 cases by 2009 in Ghana alone. None of this would have been possible if it were not for the awareness in global health, and the mission to make the world a healthier, safer place to live.
The lifecycle of a heartworms begins when a female mosquito ingest blood containing microfilariae from a heartworm infected animal. Inside the body of the mosquito, the microfilariae develops into first stage larvae (L1) and then undergoes two more process to develop into third stage larvae (L3) of which is the infective stage. Depending on the temperature, this development process can take between eight and thirty days. At this point, when the infected mosquito attaches to a cat and feeds on its blood, the third-stage larva is transferred into the mosquito bite wound. Within three days of entering the cat, the L3 molt to the L4 stage in the tissues and muscles that lay just below the skin of the cat. After about two months of migrating through the muscles and tissues, the L4 undergoes a final development into immature adult heartworms. Seventy to ninety days post infection, the immature adult heartworms then enter a peripheral vein and are carried by the cat’s blood circulation system to the caudal pulmonary arteries. This is where the majority of heartworms are cleared from the cat due to a mass immune response, but a few may continue development into adults. Once the heartworm develop into adults, they invade the heart first and then spread to other organs in the body and cause
Throughout the years the use of animals in medical research has been a hot debate around the world. Although animal testing may be cruel and inhumane, thousands of humans are saved thanks to the research that animals supply researchers with. Animals testing have taken over our knowledge of medicine and treatments to a whole different level. Animal testing also does this in a cheap and effective way. Without animals testing out knowledge wouldn’t be up to date, in other words animals’ testing is good.
Figure 2: The figure above depicts the average amount of healthy Simploids that were present within the control group (fifty) and the experimental/ treatment group (12.5). A total of fifty Simploids were experimented on in order to identify parasites as the cause of their ailment. The standard error is depicted above using vertical
Overall the mealworms for the groups weighed more after the experiment than before. The ranges of weight change varied from around 0.4 to 0.6 grams gained.
Background- This lab is being done to demonstrate the effects of stimulants on the circulatory system of blackworms. In this lab, the stimulant we have chosen to use is Nicotine. A stimulant is an agent that causes increased activity, especially in the nervous or cardiovascular systems. In this lab, we will put blackworms into the Nicotine to look at the differences in pulse rates when compared to a control. The proper name for blackworms is Lumbriculus Variegatus, they are freshwater worms most commonly found in North America and Europe. The blood in blackworms circulates from the dorsal blood vessel toward the head through a series of
In the article, “Validation of Treatment Escalation as a Definition of Atopic Eczema Flares,” there was an experiment ran to validate concepts of atopic eczema flares based on daily medicine usage, if there was an escalation of treatment or the days that topical anti-inflammatory medication was used. In the experiment data was used from two atopic eczema studies, and they were both analyzed by themselves. The data that was used from the previous studies were both based in the UK and they included children with different severities of atopic eczema. In the first study, the participants received normal care and water softener. The experiment consisted of 336 children that had moderate to severe atopic eczema. In the second study, it was to identify the flare triggers. There were
The book "An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases" by Moises Velasquez-Manoff is about the relationship between parasites and diseases. The author of the book suffers from alopecia, an autoimmune disease, where he is left with no hair anywhere on his body. The book centers around the author's claim: parasites can lessen and sometimes get rid of allergic and autoimmune disease symptoms. The most interesting part of the book was when the author, Manoff, talked about his self-experiment. Manoff travelled to Mexico where he willingly injected himself with hookworms, a parasite, to find out what would happen to his allergies and alopecia. He talks about this in the first chapter, only explaining how he decided to do it and how he injected himself, but not the results.
Table 1 displayed basic data on demographics such as gender, age, asthma history etc. Figure 1 shows a chart breaking down screening and randomization process of how many patients actually finished the twelve-month treatment. Figure 2 shows results for the four different asthma factors that can affect the enhancement of CB in AIT, and compare to other blood samples taken at month 6,7, and 12 subsequently. Table 2 displays the standard deviation scores for medicine and within six months the combination of both AIT and used together had the smaller deviation and that the scores were very close together compared to the other treatment groups. Figure 3 shows that CB enhances AIT in patients based on immunoglobulin. Table 3 shows that the standard deviation between all four treatment
1. Table 8.1 shows results of an eight-center clinical trial to compare a drug to placebo for curing an infection. At each center, subjects were randomly assigned to two groups.