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How Probiotics Affect Allergen Disease

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The use of probiotics helps improve our bodies immune system by stimulating our immune response. Taken as a supplement, probiotics produce inhibitors to help reduce immune inflammation and lower risk of developing pathogenic allergen diseases. Liu, et al. conducted a study to determine if treatment of probiotics will assist in inducing allergen-specific symptoms asthma patients have. While patients who have allergic asthma or other allergic diseases can alleviate symptoms with Allergen Specific immunotherapy (AIT), the effects were not a long-term solution by themselves. With treatment of AIT regulatory B cells (Breg) and regulatory T cells (Treg) were induced. Also, there was a decrease in the production of Immunoglobin (Ig). The…show more content…
Ones with mild asthma and sensitized only to house dust mites were selected for. In addition, thirty-four subject with no allergic history were included for a total fifty-six in the study. Patients were randomized and placed into groups accordingly, treated with either AIT, AIT/CB, CB or placebo. Once administered treatment, patients were under observation for one hour after. A blood sample was taken from each subject for baseline comparison then at months 6,7, and 12. Patients were coded and, and the sample taken was to measure specific serum IgE level. The following tests were used ELISA assay, luciferase reporter assay, flow cytometry, western blotting, and PCR. Table 1 displayed basic data on demographics such as gender, age, asthma history etc. Figure 1 shows a chart breaking down screening and randomization process of how many patients actually finished the twelve-month treatment. Figure 2 shows results for the four different asthma factors that can affect the enhancement of CB in AIT, and compare to other blood samples taken at month 6,7, and 12 subsequently. Table 2 displays the standard deviation scores for medicine and within six months the combination of both AIT and used together had the smaller deviation and that the scores were very close together compared to the other treatment groups. Figure 3 shows that CB enhances AIT in patients based on immunoglobulin. Table 3 shows that the standard deviation between all four treatment
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