Are Antibiotic Resistant Bacteria Viruses? More Than Two Million Americans?

Antibiotic resistance is a phenomenon in which germs evolve to be able to resist the action of drugs. This causes illnesses that were once easily curable with antibiotics to become dangerous infections, requiring alternative medications or higher doses. With millions of deaths increasing every year, antibiotic resistance has become one of the world's most pressing public health problems. This essay will explain the key causes of the emergence of resistant bacteria, including antibiotic misuse, inappropriate prescribing and availability of few new antibiotics, and outline relevant effects of antibiotic resistance.

Fleming in 1928. Penicillin helped to treat some common infections: step throat, boils, it would heal wounds quicker, as well as treat more serious infections such as meningitis and pneumonia. Antibiotics usually kill only weak bacteria and after some years of antibiotic usage stronger bacteria have not only survived but also became resistant to the old cure. “Doctors have started to prescribe antibiotics to cure conditions such as ear infections, sinusitis, bronchitis, non-specific upper respiratory tract infections and even common colds and flu… According to the Director of Antimicrobial Resistance, Dr. Richard Besser, each year US physicians write $50 million worth of prescriptions that are ineffectual and unnecessary.” (Elisa Bussey). The more doctors were prescribing antibiotics, the bigger the number of people who become resistant to them. Most of the European countries prescribe antibiotics to kill bacteria only in cases of life threatening conditions. Patients in the US have become accustomed to receiving antibiotics for almost any health concerns and with time, patients have started to expect such prescriptions as a norm.

Antibiotics differ from many other drugs in the fact that the treatment is for a very short time compared to drugs used to treat hypertension, diabetes, Parkinson’s, or cancer. The latter disorders have in common that the treatment, from the moment of diagnosis, is life-long. The treatment period for antibiotics is only a few weeks, making the return of investment poor. Increasing demands of authorities in both development and marketing phase and in legislation increase the costs of new antibiotics.[1] [3]

The misuse of penicillin and other antibiotics however is causing the growing problem of antibiotic resistance in which seemingly harmless infections turn to be deadly and dangerous. Antibiotics are not only casually used as treatments for bacterial infections, but are also used in agriculture and veterinary medicine, creating controversy on the proper uses of antibiotics. As advancements in the medical fields proved to be beneficial for a short period of time, today the misuse of these innovations are creating more and more problems that have proven to be dangerous to the accustomed health of the global population. Antibiotics were not always considered to be a superficial medication and, in fact, have been naturally used for millions of years, like with ants and their symbiosis with antibiotic producing fungi. Humans do not fully realize the value that antibiotics have brought to the population and do not take measures to preserve their use. In contrast, humans take for advantage the natural benefits that is given to them to overly benefit themselves, such as while creating revenue through mass production despite warning from scientists. This selfish misuse leads to consequences in which the future will have to provide solutions for, and perhaps even follow in the ants’ footsteps.

With all of our modern advances, it seems somewhat strange that chronic health problems have become so commonplace. When antibiotics were discovered, they predicted the end of disease. Instead, we now have a world full of frightening antibiotic resistant infections.

When antibiotic is used most of the bacteria die but a few bacteria with antibiotic resistance gene survive and reproduce and pass this advantage to their offsprings. This selective pressure exists naturally, however antibiotic misuse can be accused for fastening the spread of the antibiotic resistance gene [Refer to figure 2] (Learn Genetics 2015). Consequently, inappropriate antibiotic intake will lead to a greater chance of superbugs being developed. Antibiotic resistance can be defined as a new ability which a bacterium has developed to stay unattached in the presence of an antibiotic that was previously effective to destroy the bacterium (ABC science 2015). Four key mechanisms that has been identified for bacterial antibiotic resistance can be listed as: producing enzymes that inhibit the functionality of the drug, reducing the effectiveness of the drug by producing targets against which the antibiotic, reducing the permeability of the drug into the bacterium and active export of antibiotics using various pumps (Pogson 2012). All these mechanisms can be developed by any of the bacteria when the corresponding mutated gene of antibacterial resistance is received. The genes code for specific proteins, and variation in the gene leads to alteration of the shape of proteins. This leads to changing the functionality

A current predicament in the field of science is antibiotic resistance against superbugs.Though fighting against superbugs; which can be defined as a strain of bacteria unable to be killed using multiple antibiotics, is now a large problem, in the past it was not. The evolution of resistance in bacteria due to antibiotic abuse and lack of product development has brought upon us once again the fear of a pre-antibiotic era; one where simple, once easily defeated infections could kill. Already, infectious diseases are the 3rd leading cause of death in the US and the 2nd across the entire world, and drug resistant superbugs send 2 million Americans to hospitals every year; killing 23,000 of those people. And any bacterium can quickly and easily become multidrug resistant, the leading cause of this being antibiotic misuse in both humans and animals.( "Clinical Infectious Diseases." The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America. UCLA Medical School. Web. 27 Mar. 2016.)

A huge advancement was made in the world of medicine when antibiotics were first invented. Suddenly, deadly diseases such as Staphylococcus could be cured. (Tan, 2014) Before antibiotic discovery in 1928, and their prescription in the late 1930’s, Streptococcus pyogenes caused 50% of post-birth deaths, and was a major cause of death in burn victims. Staphylococcus aureus killed 80% of people with infected wounds, and tuberculosis and pneumonia ran rampant within the population. Through the use of antibiotics, these diseases could be easily treated. Between 1944 and 1972, human life expectancy leaped by eight years, primarily accredited to antibiotics; and the number of people dying due to bacterial infection dramatically fell. (Australian Broadcasting Corporation, 1999) Therefore, antibiotics are beneficial as they are able to save lives, and treat various types of bacterial diseases. In addition they are easily administered - they may simply be taken orally, or injected. They are also cost-effective, and have few side effects. Moreover, the cost of antibiotic regulation, public ignorance of the threat, and adherence to routine are major factors preventing regulation laws to be put in place. (Krans,

Before antibiotics were discovered, bacterial infections like strep throat and meningitis were untreatable and often deadly. Things that seem easily treatable to us now, like an ear infection, could mean a death sentence to those with weak immune systems, such as the very young or the elderly. Antibiotics were first discovered in the form of penicillin by Alexander Fleming in 1928, but its true power wasn’t recognized until the 1940s after more medical testing was conducted. Once the commercialization of antibiotics began, it was declared a ‘miracle drug’ and its use skyrocketed to the number of prescriptions we see today, about 150 million a year (“History of Antibiotics”). Antibiotics have saved millions of lives, and without a doubt have improved the quality of life of many people around the world, but unfortunately, not everyone uses them correctly. Overuse of prescription antibiotics is becoming increasingly common, with some people hoarding leftover pills and needlessly taking

Antibiotics has played a huge role in the field of medicine since it was first discovered in 1928. Antibiotics are antimicrobial drug that kills or inhibits growth of diseases which prevents many illnesses. However, in the past decade, Antibiotic resistant bacteria has become the world’s latest pandemic. Many strains of bacteria have adapted and developed resistance against antibiotics. According to the CDC, “at least two million people are infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections.” (CDC) This is a problem because antibiotics are the number one defense tactics against bacterial infections. Without this line of defense, people vulnerable to bacteria growth which can cause problems in health.

Throughout the centuries the improvement of medicine has always been on the run. Whether the cure for a viral or bacterial infection to the simple cure of a common cold, advances in medicine can be said to have had a great impact in the lives of many in the U.S. and around the world. In the U.S. alone, the life expectancy of an American increased from 49 years to 77 years because of the new way of life in the health aspect. There is no doubt that antibiotics specifically, not to say the prevention of diseases by public health regulations including over-the-counter drugs and surgical procedures, have saved thousands or even millions of lives in the U.S and around the world. However, there are many cases in which antibiotics are being overused, which in effect cause more harm than good.

When antibiotics were discovered in the early 1900’s, it revolutionized the medical world forever. Before this discovery millions and millions of people died from minor infections; there was not anything to fight off the growing bacteria. There are many types of antibiotics but the discovery of penicillin was first and it would leave everyone amazed and alive to this day.

decades in the past. Antibiotics have impacted the world, and have had a ubiquitous influence,

The overuse of antibiotics has been a problem for well over a decade. This misuse leads to many nonvisible problems arising within the human population. As the use of antibiotics increases, the number of antibiotic resistant bacteria also increases. When bacteria become resistant to an antibiotic, another antibiotic must be used to try and kill it and the cycle becomes vicious. Michael Martin, Sapna Thottathil, and Thomas Newman stated that antimicrobial resistance is, “an increasingly serious threat to global public health that requires action across all government sectors and society” (2409).

"Antibiotics continue to be powerful weapons to fight infection, but inappropriate use makes the treatment of microbial infections increasingly challenging. Successful antibiotic stewardship can help mitigate the development of antimicrobial resistance and lead to better outcomes (MLO, 2016)." The first antibiotic introduced and produced in the United States was penicillin in the 1940's. From 1940 to 1960 more than 20 new classes of antibiotics were introduced, and resistant strains developed within five years of each new class. Although the research for new antibiotics has stalled, the use and distribution of antibiotics has increased (Smith, 2015).