Bisphenol-A (or BPA) is an organic compound used in the industrial production of plastics. It was first synthesised around 100 years ago, and has been used to produce polycarbonate plastics and epoxy resins since the 1960s (US-FDA, 2012). Polycarbonate plastics are lightweight and rigid, therefore used in products such as CDs, DVDs, sports and medical equipment, food and drink containers and some water supply pipes. Epoxy resins are used as protective coatings in food cans, paints and adhesives (Aschberger, 2010). According to the US Environmental Protection Agency, there are over three million tonnes of BPA produced worldwide each year. Humans are exposed to BPA as it has the ability to hydrolyse (react with water) when catalysed by hydroxide, …show more content…
When digested, BPA is absorbed into the bloodstream through the intestinal wall. The blood is then transported directly to the liver by the hepatic portal vein. During this time it reacts with glucoronic acid or sulfuric acid in the bloodstream to form BPA-glucoronide or BPA-sulfate respectively (Aschberger, 2010). These reactants are water soluble and therefore can be rapidly eliminated through the urine. It is for this reason that the US Environmental Protection Agency states that BPA has a low bioaccumulation potential. Furthermore, when in the form of BPA-glucoronide or BPA-sulfate, the shape of the molecule has changed and cannot bind to any hormone receptors. Each hormone receptor has a specific shape, by which only hormones complementary in shape will bind. However, in tissue sites containing the enzymes -glucoronidase and arylsulfatase-C, BPA-glucoronide and BPA-sulfate react to produce the free form of BPA (Aschberger, 2010). These enzymes are present in higher concentrations within the placenta, leading the US Food and Drug Administration to suggest that foetuses have a higher exposure level to BPA than …show more content…
For example, Lang et al (2008) claims that higher levels of BPA in the urine were associated with cardiovascular disease and type-2 diabetes. However, higher levels of BPA in the urine could also suggest a high consumption of packaged food. The packaged food is higher in sugar, salt and fat content, therefore would lead to a higher risk of type-2 diabetes. The US Environmental Protection Agency concludes that these studies “are insufficient for use in risk assessment because of a variety of flaws in some of the study designs”. They further question the findings stating that there is an “inability of other researchers to reproduce the effects in standardised
The overall food contamination by Bisphenol A is unknown, but the nutrition/ health impact of this chemical is an important subject to be discussed for all individuals. The main aim of one study recently analyzed was to assess the reproductive impact of BPA leached from regularly available polycarbonate plastic containers. The bottles specifically chosen for testing were those that were used by children. The migration of BPA occurs in polycarbonate plastics (i.e. water bottles and baby bottles). Toxicology reports show society the importance of evaluating these products before purchase and consumption as a consumer. For a particular experiment, researchers used Daphnia Magna, a small flea that cleans and absorbs particles that infect the solution they are placed in, and bred them in the polycarbonate containers. A control group was created using water bottles without the infection of these creatures. A GC-MS machine to detect the level of BPA released by each polycarbonate plastic then evaluated the water. An increase in the reproduction of BPA was detected when the Daphnia Magna were bred inside the container. Although these organisms effected the leaching of Bisphenol A, the GC-MS was able to detect, through the control group, that BPA is released without DM. An Eco toxicological effect was observed through all of this testing, and provided evidence to substantiate the fact that Bisphenol A is leached from polycarbonate plastics. The BPA was further analyzed in the Daphnia
A “commodity chemical,” BPA is widely used in consumer products, and therefore is produced on a large scale. It is composed of two polymers: acetone and phenol. The two primary uses of BPA are for polycarbonate plastics (approximately 74% of its application) and epoxy resins (about 20%) (Ritter). Polycarbonates are manufactured by the combination of phosgene (COCl₂) and BPA (C15H16O2 ), and epoxy resins are made by combining BPA and epichlorohydrin (C3H5ClO). When unpolymerised epoxy compounds leach into food through packaging or come into contact with human skin through contact with cash register receipt tapes, for example, the estrogen-mimicking effects of the compounds have the potential to interfere with the normal function of
Bisphenol A, also known as BPA, is a hidden but deadly assassin that has been used to harden plastic products for decades. BPA can be found in medical devices, dental sealants, water bottles, and canned foods (The Facts). Even if we tried to avoid this spiteful chemical, we couldn’t. It is everywhere. However, you can still cut down on the amount of BPA you are in contact with but
In the year 2011 there were many reports in the media regarding bisphenol A (BPA). BPA is a hormone-disrupting chemical linked to adverse health effects like cancer, infertility, diabetes, obesity and ADHD (Newbold, 2009)
This is because the chemical has one of the most common environmental chemical exposures to humans. Abbreviated “BPA”, bisphenol A exposure, has been linked with several mechanisms that are involved in the development of cardiovascular disease, this comprises of weight gain, insulin resistance, thyroid dysfunction, endothelial dysfunction, and oxidative stress (NHANES 11).Public health places emphasis that the health of populations should be considered by reducing the quantity of bottled water they consume. Data should be collected for the purposes of policy decision making and deciding the best ways the consumption of bottled water should be curtailed Considering that an endocrine-disrupting chemical, BPA has been shown to have estrogenic and thyroid hormone that disrupts the effects of experimental studies. This owes to the fact that there are significant relations between childhood obesity and the type of water such children who get infected by the disease consume. The venture hence becomes a serious concern because people, specifically Americans, have been unknowingly poisoning themselves and their children with the prior mentioned chemical. This has been championed by the use of BPA contained in bottled water. Notably, only reduces human consumption of this harmful chemical which is found 93% of the American adult
In his article, “Why the FDA Hasn’t Banned Potentially Toxic BPA (Yet),” Bryan Walsh seeks to explain the reasons why the FDA hasn’t banned a possibly dangerous chemical from consumers products. Biomonitoring makes looking for microscopic-level doses of chemicals in the body possible. One of them, Bisphenol-A, or BPA for short, is used to harden polycarbonate plastics and manufacture epoxy resin, which are found in everyday products. BPA poses a threat to human health since it disturbs the endocrine systems in our body; which can lead to cancer, heart disease, and other life-threatening diseases. However, the FDA refuses to ban the chemical due to studies having a lack of research done on actual humans, but the NRDC argues that it is hard for
is a difficult chemical to escape -- it's in so many plastic products from water bottles and sippy cups to contact lenses and toys. Controversial studies linking BPA to health risks, particularly reproductive risks, prompted companies to go the "BPA-free" route. But new research from the University of California - Los Angeles (UCLA) Health Sciences says not so fast: BPS (Bisphenol S), a replacement for BPA that technically makes products BPA-free, is probably not safe either.
Polychlorinated biphenyls (PCBs) are a group of manmade chemicals. They are oily liquids or solids, clear to yellow in color, with no smell or taste. Over the years PCBs have been released into the environment through spills, leaks from electrical and other equipment, and improper disposal and storage. It is estimated that more than half of the PCBs produced have been released into the environment. Once in the environment, PCBs can be transported long distances and they bind strongly to soil and sediment so they tend to be persistent in the environment. They have been found in air, water, soil, and sediments throughout the world. How this will impact the world is that PCB’s can enter the body by eating or drinking contaminated food, through
Bisphenol A or better known as BPA is a synthetic compound that is used to make several different items. BPA was founded in the 1890’s by a Russian chemist. It was initially tested in the 1930’s as a substitute for estrogen, but upon testing found it less effective than estradiol. In 1953 polycarbonate resin was invented. This was a strong plastic material which was initially used for wiring, fuse boxes, distributors and glazing. During that same period it was found useful in making plastic bottles and lining of metal cans. It wasn’t approved by the FDA until the 1960’s for food packaging. It is also used in recycled paper used to print out receipts from stores (Caliendo, 2012)
This is supported by in vitro fertilization in humans which show higher rates of implantation failure in women with a higher urinary concentration of BPA.
Everyone one at some point in their life has drank from a plastic bottle, whether it was a baby bottle, a plastic disposable water bottle, or just a water bottle you have used for exercise. If you were to show someone one of these thing they would know what it is, but what they might not know is that it can be harmful to them. A while back a lot water bottles used to be made with something called BPA, which has been proven to have many side effects on people when it get absorbed into from the plastic to your water. In this paper I will be informing you on BPA, what it is on how it gets into your water, what side effects it can have on you, and are water bottle safe for you now.
Polychlorinated biphenyls (PCBs) are a class of organic compounds use in a variety of applications, including dielectric fluids for capacitors and transformers, heat transfer fluids and as additives in adhesives and plastics. PCBs have been shown to cause cancer in animals. PCBs have also been shown to cause a number of serious non-cancer health effects in animals, including effects on the immune system, reproductive system, nervous system, endocrine system and other health effects. PCBs are persistent contaminants in the environment. Due to the high lipid solubility and slow metabolism rate of these chemicals, PCBs accumulate in the fat-rich tissues of almost all organisms (bioaccumulation). The use of PCBs
processing of it, there is a potential danger to humans. Bisphenol A is a molecule that is a
The use of bisphenol A (BPA) in consumer products has been controversial and reemerging as a purported threat to public and environmental health. Since its first uses as a xenoestrogen in the early 1900s, BPA is now used extensively in plastics, food packaging, thermal receipts, and dental products. With estimated annual production of BPA exceeding 4 million metric tons, humans are exposed to BPA through a variety of routes, including ingestion through dietary sources, dermal exposure through thermal receipts, and inhalation of household dust (Michalowicz, 2014). Animal research models have extensively demonstrated the endocrine disrupting potential of BPA. Furthermore, correlational epidemiological studies in humans have
The main goal of this current study that I choose to examine was to “characterize the serum and urine concentration time-courses for BPA in humans following controlled oral cavity exposure in a manner that reflects typical human exposure to BPA in liquids, like soup or beverages.” An ordinary food item was selected since this would account for 90-99% exposure in both adults and children. A commercial soup product, which is a liquid carrier of BPA, was more appropriate to use instead of a solid food due to its higher surface area contact and absorption. The soup was exposed to humans by a normal feeding routine.