Christina Tebbe
Introduction
24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup
Toxicology and Applied Pharmacology
Authors: Justin G. Teeguarden, Nathan Twaddle, Mona I. Churchwell, Xiaoxia Yang, Jeffrey W. Fisher, Liesel M. Seryak, Daniel R. Doerge
Published January 2015
Bisphenol A (BPA), which is a monomer that can be used in the manufacturing of polycarbonate plastics and certain can liners, and is also found in certain consumer products and food containers (Chapin et al., 2008). It is currently accepted that BPA is safe as the way it is used, and that the major intake of BPA is from the diet and there are assessments confirming this with showing no other
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The main goal of this current study that I choose to examine was to “characterize the serum and urine concentration time-courses for BPA in humans following controlled oral cavity exposure in a manner that reflects typical human exposure to BPA in liquids, like soup or beverages.” An ordinary food item was selected since this would account for 90-99% exposure in both adults and children. A commercial soup product, which is a liquid carrier of BPA, was more appropriate to use instead of a solid food due to its higher surface area contact and absorption. The soup was exposed to humans by a normal feeding routine.
Results
The volunteers of this study 1 prior to ingesting BPA were first administered breakfast. They were then given a commercial tomato soup, which contained a 30 μg/kg bw dosage of deuterium labeled (d6) BPA (d6-BPA). Blood samples would be drawn right before the soup was ingested as well as drawn regularly throughout the 24 hour period of study. Urine samples were collected over a
The overall food contamination by Bisphenol A is unknown, but the nutrition/ health impact of this chemical is an important subject to be discussed for all individuals. The main aim of one study recently analyzed was to assess the reproductive impact of BPA leached from regularly available polycarbonate plastic containers. The bottles specifically chosen for testing were those that were used by children. The migration of BPA occurs in polycarbonate plastics (i.e. water bottles and baby bottles). Toxicology reports show society the importance of evaluating these products before purchase and consumption as a consumer. For a particular experiment, researchers used Daphnia Magna, a small flea that cleans and absorbs particles that infect the solution they are placed in, and bred them in the polycarbonate containers. A control group was created using water bottles without the infection of these creatures. A GC-MS machine to detect the level of BPA released by each polycarbonate plastic then evaluated the water. An increase in the reproduction of BPA was detected when the Daphnia Magna were bred inside the container. Although these organisms effected the leaching of Bisphenol A, the GC-MS was able to detect, through the control group, that BPA is released without DM. An Eco toxicological effect was observed through all of this testing, and provided evidence to substantiate the fact that Bisphenol A is leached from polycarbonate plastics. The BPA was further analyzed in the Daphnia
Arguments in favor of BPA’s continued commercial use center on the assertion that each exposure is so minimal that the lifetime risk to human health is not serious enough to call for a ban on a chemical with a variety of commercial applications. While the argument appears to focus on degree of exposure rather than on a debate about whether or not chemicals do, in fact, have the potential to leach, vulnerabilities in certain individuals make the specific “safe” exposure level difficult to identify definitively.
Bauer also states, “...and prostate gland of fetuses, infants and children. Additional research suggests a possible link between BPA and increased blood pressure” (What is BPA?). I propose that our society has adapted to the horrifying chemicals that are everywhere, except has been and always will be around us. Thus, my grandparents have been around this toxic chemical for far too long, and was slithering into their bodies the longer that they have been present--as it will for myself. Therefore, BPA and many other toxins could have played a role in leading my grandfather to having prostate cancer due to working in the construction business for so long, and my grandmother could have high blood pressure due to the handful of dental surgeries she has undergone throughout her life. Meanwhile, this list does not include that they both wear glasses which also contain very high concentrations of BPA to permit the glasses to not bending and breaking. Not only has it been a rocky road for my grandparents, it may be even worse for myself due to the fact that BPA mainly enters our bodies through our diets from canned and processed foods
Phthalates are used in almost every product, from foods to plastics (Fda, 2014). However, not all the health effects of this have been studied, and the ones that have been done, show that it is harmful. Why is it still around then? This essay will investigate the biochemical effects of phthalates as well as the advantages and disadvantages of its use to answer the following question: Should phthalates be allowed to be used in children’s toys? This paper, will be looking at the uses for phthalates, and then looking at the possible health effects that it may have. Then, it will be determined if the benefits out way the bad, or the other way around.
This is because the chemical has one of the most common environmental chemical exposures to humans. Abbreviated “BPA”, bisphenol A exposure, has been linked with several mechanisms that are involved in the development of cardiovascular disease, this comprises of weight gain, insulin resistance, thyroid dysfunction, endothelial dysfunction, and oxidative stress (NHANES 11).Public health places emphasis that the health of populations should be considered by reducing the quantity of bottled water they consume. Data should be collected for the purposes of policy decision making and deciding the best ways the consumption of bottled water should be curtailed Considering that an endocrine-disrupting chemical, BPA has been shown to have estrogenic and thyroid hormone that disrupts the effects of experimental studies. This owes to the fact that there are significant relations between childhood obesity and the type of water such children who get infected by the disease consume. The venture hence becomes a serious concern because people, specifically Americans, have been unknowingly poisoning themselves and their children with the prior mentioned chemical. This has been championed by the use of BPA contained in bottled water. Notably, only reduces human consumption of this harmful chemical which is found 93% of the American adult
BPA is a synthetic organic compound which is also known as Bisphenol A and can be found in many items that we use everyday (Withcott & Laposata, 2012). Some of items that the compound can be found in consists of the lining of metal food cans, drink cans and the pipes that supply our water. Also, it is used in plastic water bottles, baby bottles, food containers, our food utensils and electronics. This same compound can move into our food, air and body just by using these products. Research has found that it is detected in an individual's urine and that we are exposed to BPA continuously.
In the year 2011 there were many reports in the media regarding bisphenol A (BPA). BPA is a hormone-disrupting chemical linked to adverse health effects like cancer, infertility, diabetes, obesity and ADHD (Newbold, 2009)
More than 90% of us have BPA in our bodies right now. Bisphenol A (BPA) is a harmful chemical used to manufacture most plastics and cans. It is also found in most water bottles and baby formulas. Although many people use processed goods daily, they have very harmful chemicals in them such as BPA. BPA can lead to many major health issues such as problems in the central nervous system, cardiovascular disease, and even cancer.
It is frequently used to make plastic more flexible in objects such as food storage containers, toys and tools which are used daily by majority of the population (PHSDP, 2015). There has not been a substantial amount of research done on this particular chemical and the public does not know much about this substance’s effects. Although there has not been any studies conducted on how diethyl phthalate directly affects humans, some have been conducted on laboratory animals. It was revealed that large amounts of diethyl phthalate consumed by mouth, is lethal to test animals while small amounts at brief exposure times appeared harmless (PHSDP, 2015). Therefore, with this limited information on diethyl phthalate, this experiment will provide more insight on the potentially hazardous chemical that is constantly exposed to the human population. After studying the effects of diethyl phthalate on the development and mortality rates of Artemia salina, a conclusion can be reached regarding how different exposure times and concentrations can affect a common primary consumer that is necessary in many
A study by the Centres for Disease Control and Prevention (CDC) in 2003 concluded that there were noticeably higher levels of BPA found in 93% of 2,517 urine samples taken by people over the age of six. This particular date is considered the main source for further action in the United States. Because BPA is used in the manufacturing of most drink bottles, raising concern for parents. Most baby bottles contain BPA and it can seep into the liquid making consumption inevitable (Forbes. 2015). BPA is known as an ‘endocrine disrupter’ this is defined as “a substance which interferes with the production, secretion, transport, action, function and elimination of natural hormones.” This means that this chemical can imitate the body’s own hormones, which can be dangerous, especially for young children still developing, as it changes and may decrease the production of Luteinizing hormone (LH) this can change the rate in which children go through puberty (Mayo Clinic . 2015). This hormone is also responsible for the ovulation of women, a study in 2006 found that rats exposed to BPA for long
A lot of people believe they're eating healthy but are actually consuming foods and ingredients that are toxic. If you're on the path to leading a healthier life, then make sure you're not eating these cancer-causing foods.
Once you open your eyes to it, it’s everywhere, from the Tupperware you eat out, the cans that your food is packaged in, to the helmets you put on your head and the laptop that you’re using. BPA has been used as a plastic hardener for the past 40 years now and is now deeply engrained in our products of modern consumer society. Although it’s children and unborn babies that are the most affected by this toxic chemical, adults are not exempt form
During the early 1990s, Dr. Feldman became the first researcher to identify the possible impact of low levels of BPA. Feldman and his team discovered an estrogenic molecule while growing yeast in plastic flasks in 1992. They discovered the yeast wasn’t synthesizing the estrogen, but rather it was leaching from the plastic. The team then performed a control experiment without the yeast in the flask, and they found there was still an estrogenic molecule present, which they later identified as BPA. Once they made the connection between polycarbonate, BPA and estrogenic activity, Feldman and his team contacted a major producer of polycarbonates. It turns out, the company had already looked into the leeching issue, but after using their own methods, they said they “couldn 't find any estrogenic activity.” Other studies soon popped up, including the University of Missouri-Columbia that found low-level exposure to BPA may harm the prostate. Over the next decade, reports on low-dose BPA toxicity will grow to include more than 100
Human exposure can occur through multiple routes, however oral exposure is the major route of exposure to BPA, thus, oral exposure occurs because of the leaching of BPA from polycarbonate containers and from the plastic lining of cans (Chris et al., 2009). Furthermore, BPA is also detected in indoor air primarily associated with dust, which indicates exposure can occur through inhalation (Taylor, 2008). Exposure to BPA in humans received dramatic attention when it was detected in serum, follicular and amniotic fluids, fetal serum, milk of nursing mothers, and in the urine (Gould et al., 1998). BPA as one of the potential EDCs to health risk and may interfere with the production or activity of hormones in the human endocrine system (Gould et
The FDAs most recently published evaluation of BPA is the 2014 Updated Review of Literature and Data on Bisphenol A (CAS RN 80-05-7). The memorandum states that their research continues to support their stance that BPA is “quickly and efficiently metabolism once Ingested” (Aungst and Anderson 2014, June 6) and therefore, safe for consumers. However, the 2014 review does acknowledge that it had “identified three endpoints as potential hazards although with low confidence due to study limitations, conflicting reports, and current understanding of potential for unintended exposure or contamination. The hazard identification endpoints are developmental neurotoxicity related to molecular or neuroanatomical endpoints with varying routes of administration, cardiovascular disease-related factors based on human epidemiology studies, and sperm/testicular/hormone related parameters based on very limited