A Research Study On Bisphenol A ( Bpa )

Decent Essays
Christina Tebbe


24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup
Toxicology and Applied Pharmacology
Authors: Justin G. Teeguarden, Nathan Twaddle, Mona I. Churchwell, Xiaoxia Yang, Jeffrey W. Fisher, Liesel M. Seryak, Daniel R. Doerge
Published January 2015

Bisphenol A (BPA), which is a monomer that can be used in the manufacturing of polycarbonate plastics and certain can liners, and is also found in certain consumer products and food containers (Chapin et al., 2008). It is currently accepted that BPA is safe as the way it is used, and that the major intake of BPA is from the diet and there are assessments confirming this with showing no other
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The main goal of this current study that I choose to examine was to “characterize the serum and urine concentration time-courses for BPA in humans following controlled oral cavity exposure in a manner that reflects typical human exposure to BPA in liquids, like soup or beverages.” An ordinary food item was selected since this would account for 90-99% exposure in both adults and children. A commercial soup product, which is a liquid carrier of BPA, was more appropriate to use instead of a solid food due to its higher surface area contact and absorption. The soup was exposed to humans by a normal feeding routine.


The volunteers of this study 1 prior to ingesting BPA were first administered breakfast. They were then given a commercial tomato soup, which contained a 30 μg/kg bw dosage of deuterium labeled (d6) BPA (d6-BPA). Blood samples would be drawn right before the soup was ingested as well as drawn regularly throughout the 24 hour period of study. Urine samples were collected over a
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