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Bpa Is A Known Endocrine Disruptive Chemical ( Edc ) With Adverse Developmental Effects

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BPA is a known endocrine disruptive chemical (EDC) with adverse developmental effects. It is known that BPA exposure causes respiratory problems like asthma and wheeze children.
This study evaluates the prenatal exposure to BPA via maternal diet and its effects on lung maturation. The exposed groups of pregnant mice were had diets supplemented with 5, 25 or 50 mg BPA/kg. For the recovery studies, BPA exposed and control pregnant and mice were injected with dexamethasone and saline respectively at E16.5 and E17.5.
After the mice were euthanized at E18.5 there was no significant difference in fetuses’ weight between the control and the BPA exposed fetus. The lungs had no organizational differences, but the BPA exposed fetal lungs from the diets supplemented with 25 and 50 mg BPA/kg showed signs of lung immaturity (reduced alveolar space and thickening of the alveolar septa). The biochemical analysis was made from the 25 mg BPA/kg BPA-fed group.
BPA increased the content of glycogen (50% of the control value), show adverse effects on type I epithelial cells, reduced glucocorticoid target genes (epithelial sodium channel ɤ and glutathione peroxidase), and show no statistically significant difference in fetal plasma levels of corticosterone at E18.5 and E15.5.
Nevertheless, the fetal lungs with administration of dexamethasone in the recovery studies, showed no difference in alveolar airspace and septa thickness in comparison to the control group, suggesting that the BPA
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