Breast Cancer Essay

Decent Essays

developing breast cancer, there presence alone does not always result in breast cancer. The two genes that are indicative of breast cancer are BRCA1 and BRCA2. However, these genes are not the only indicators of breast cancer, although, there presence carries the greatest chance of development. The other genes that also serve as indicators of possible breast cancer are CHEK2, PTEN, TP53, PALB2, STK11, and CDH1. These genes are extremely significant because the presence or absence of a mutation form can either prohibit or enable the development of breast cancer. CHEK2 is an abbreviation for checkpoint kinase 2 and is responsible for the creation of a protein that suppresses tumor growth. The presence of this gene being mutated doubles the …show more content…

Peutz-Jeghers syndrome is a genetic disease in which benign tumors develop in the gastrointestinal tract. CDH1 is an abbreviation for Caherin 1 and is a tumor suppressor gene that enables the attachment and organization of cells to form tissues. A mutation in this gene can increase the risk of developing cancer because it can allow a cancer cell to break off and form breast cancer. All these genes proper expression play a large role in prohibiting the growth of tumors. In most cases it is not simply the presence of a mutated form of BRCA1 or BRCA2 that causes the development of breast cancer but a combination of mutated forms of these genes as well. Thus, it is incredibly imperative to not only analyze BRCA1 or BRCA2 but also STK11, CDH1, PALB2, CHEK2, P53 and PTEN as their presence can multiply the chances of an individual developing breast cancer. The ultimate transmission of breast cancer “interest genes” is not solely based on BRCA1 and BRCA2, but more accurately and often it is the presence of a mutated form of either of those previously listed and the presence of a mutated form of one of many of the tumor suppressors or localizers. A study conducted by Dr. Lineberger of the University of North Carolina on the molecular mechanisms of breast cancer progression noted that, “The development of breast cancer is thought to occur through a multi-step process. The majority of breast cancers

Get Access