Breast cancer (BRCA) is associated with the highest mortality rate of any type of cancer besides that of the lung (American Cancer Society, 2013). BRCA occurs most commonly in women over the age of 40, with an estimated global incidence of 1.6 million cases in 2010. An estimated 39,000 women died from BRCA alone in 2013 (American Cancer Society, 2013). BRCA is responsible for the largest portion of spending on cancer-related care in the United States; an estimated $16.5 billion of cancer-related spending went towards BRCA in 2010 (Mariotto, Robin Yabroff, Shao, Feuer, & Brown, 2011). Although the prevalence, mortality, and costs associated with BRCA are quite high, recent advances in screening and treatment have increased long term …show more content…
Common side effects of chemotherapy include: nausea and vomiting, hair loss, appetite loss, pain, fatigue, depression, anxiety, problems with concentration and memory, and sleep disturbances, among others (American Cancer Society, 2013). These side effects take a toll on patients, and contribute significantly to decreased QOL, even after finishing treatment (McDonald et al., 2010). Systemic inflammation, resulting from both the disease process and treatment with chemotherapy, has been suggested as an underlying factor contributing to the observed side effects. Research into these inflammatory processes appears to support this notion (Bower et al., 2011; Pomykala, Ganz, et al., 2013).
Overview of Inflammation
When tissue injury occurs, a network of chemical signals activate a host response which is designed to protect and heal the damaged tissues (i.e. inflammation) (Coussens & Werb, 2002). This process involves the activation and migration of leukocytes (neutrophils, monocytes, and eosinophils) to the site of damage as well as recruitment of tissue mast cells (Coussens & Werb, 2002). Additionally, this inflammatory response involves migration of macrophage progenitors, which travel through the venous system to the site of injury. This migratory process is directed to the site of tissue damage by a host of chemotactic factors, among these are cytokines including interleukin-1β (IL-1β) and
Breast cancer is a complex disease that will affect around 1 in 9 Canadian women during their lifespan. According to the latest statistics, it is found that around
We have all seen the pink ribbons. They have become a national, if not international symbol for breast cancer support and awareness. Breast cancer knows neither racial boundaries nor age restrictions. Females of all ages and ethnicities can develop breast cancer and it is the leading most common cancer among women. Calling attention to this often fatal disease is important by supporting its victims, families and friends of victims, as well as raising funds for breast cancer research. Though males are not immune from developing a breast cancer, for the purposes of this paper, this paper will be limited to information relating breast cancer in females.
According to the United States Breast Cancer Statistics (2016), in 2016 there will be an estimated 246,660 newly diagnosed cases of invasive breast cancer and 61,000 of non-invasive breast cancer among women. For this reason, when studying breast cancer based on a large-scale impact, it not only affects the patient themselves but, as well as their families and communities nationwide. Furthermore, many contributing factors lead to this being such a public health issue. Conclusively, there are specific programs, services, and policies that help to assist the contributing factors of such a public health threat. Nevertheless, breast cancer is still an increasing concern in society, and much-needed research is required to be able to detect and treat this disease.
Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Breast cancer is the second most commonly diagnosed cancer in women. (Only skin cancer is more common.) About one in eight women in the United States will develop invasive breast cancer in her lifetime. Researchers estimate that more than 230,000 new cases of invasive breast cancer will be diagnosed in U.S. women in 2015. Cancers occur when a buildup of mutations in critical genes—those that control cell growth and division or repair damaged DNA—allow cells to grow and divide uncontrollably to form a tumor. Breast cancer can be caused by inherited genetic factors. These genetic
Cancer of the breast is the most common type of non-skin cancer affecting women. It also comes second after lung cancer in the number of deaths among the African-American population in 2017; the American Cancer Society estimated that there would be approximately 252,710 new cases of breast cancer which is considered invasive that will be diagnosed in the United States. More so, nearly 63,410 new cases of (CIS) carcinoma in situ will be detected, and approximately 40,610 women will depart this life as a result of cancer of the breast(Siegel, Miller, & Jemal, 2015).In the United States, the incidence of cancer of the breast is not similar among the African America women and the white. Such that, it has been noted that the
Breast Cancer is the most common misfortune in women and second leading cause of death by cancer. Today, woman with breast cancer have a 90% chance of surviving for five years post-diagnosis. However, African American women have a national survival rate of 79%. Socioeconomic barriers and lack of access to health services have crippled African American women in breast cancer advancements. Studies have show that African American women tend to be diagnosed with a higher-stage of cancer because of the delay of being tested until it is late in the stage. African American women in contrast to their white counterparts generally have a more aggressive stage of breast cancer and therefore a shorter survival rate. These startling statistics bring
This paper will inform you of Breast Cancer. It is the most common form of cancer in women today but thanks to medical advances it is no longer the number one killer of women.
Ovarian cancer is cancer of the ovaries and is listed as the fifth cause of death in women. Ovaries are the reproductive glands of only females and the main source of a female’s estrogen and progesterone. The ovaries are made up of 3 kinds of cells, which can also develop different types of tumors. Epithelial tumors start from the cell that covers the outer surface of the ovaries. Germ cell tumors start from the cells that produce the eggs. Stromal tumors start from the structural tissues that hold the ovary together and produce the female hormones (1).
Breast cancer is a type of cancer where a malignant tumor is formed in the breast, which continually grows and infects the surrounding tissues [1]. This type of cancer is the most common type of cancer found in women. On average about 26% of women developed breast cancer in 2015 [2]. There are multiple signs and symptoms that can help one become aware if they have the disease. The most prominent key feature is the presence of a lump in your breast or armpit. Such signs may be indicative of breast cancer. In addition changes in the breast and the skin around it are also good indicators. So if the skin around your breast as well as the surrounding nipple becomes puckered or dimpled, it is recommended to go and consult a physician. The inverting or crusting of the nipple may also present as symptoms. However, these are all early onset signs. If the cancer has been in your body for a longer period of time, one might experience things such as bone pain, nausea, weight loss, shortness of breath etc. This is usually an indicative point that the cancer has spread to different parts of the body. If the cancer continues to persist in the body without treatment, it can result in various detrimental effects. The symptoms one may already have are likely to worsen with the addition of new symptoms. Though every cancer differs in its effects and symptoms, the ideology behind it remains the same in that the body is unable to control cell division. Therefore, the cancer will continue to grow
Female breast cancer is the second most common cancer in the world with over 1.6 million cases diagnosed in 2012 (Australian Bureau of Statistics, 2012). Deaths from breast cancer within Australia have increased by 380% from 2003 to 2012 (ABS, 2012)(Smith et al., 2012). An individual’s risk of developing breast cancer increases dramatically with age until 50 where it plateaus giving women a 1:8 lifetime risk (Kamangar et al., 2006)(Davies, 2012). There are several varieties of breast cancer with the most frequent being invasive ductal carcinoma (Fernandez-Vega et al., 2013).
Before going in depth, let us first define what breast cancer is. According to the National Breast Cancer.Org “Cancer is a broad term for a class of diseases characterized by abnormal cells that grow and invade healthy cells in the body. Breast cancer starts in the cells of the breast as a group of cancer cells that can then invade surrounding tissues or spread (metastasize) to other areas of the body.” Cancer begins in the cells which are the basic building blocks that make up tissue. Tissue is found in the breast and other parts of the body. Sometimes, the process of cell growth goes wrong and new cells form when the body doesn’t need them and old or damaged cells do not die as they should. When this occurs, a build up of cells often forms a mass of tissue called a lump, growth or tumor.
Every minute a woman dies of breast cancer. Breast cancer is the most common type of cancer among women. Every year, invasive breast cancer is diagnosed in 180,000 women alone. Doctors have not been able to find the cure yet, but they are not giving up. Thanks to nonprofit charities, such as the Susan G. Komen, researchers are receiving enough money that is donated to breast cancer to look deeper and try to find ways to cure and to help prevent such a fatal disease. It’s really important for not only women to understand the symptoms but men, too. Early detection of breast cancer helps prevent fatalities among men and women.
Most people know breast cancer is a dangerous type of cancer that affects both men and women. Author Gayle Sulik of Pink Ribbon Blues: How Breast Cancer Culture Undermines Women 's Health describes breast cancer as, “abnormal cells [that] appear in the ducts (tubes that carry milk to the nipple) or the lobules (glands that make milk) and, more importantly, have the capacity to spread (metastasize)” (164). Breast cancer can be treated with surgeries and chemotherapy, radiation, and hormonal therapies. However, a person can still die even with treatment if the cancer metastasizes to major organs, like the brain and liver. For breast tumors and cancer to be diagnosed early, it is important to complete self-breast examinations and take the
Breast cancer is a major burden of disease for females in Australia. It is defined as the abnormal growth and uncontrolled division in breast cells resulting in cancerous cells that can invade and damage surrounding tissue (Montaruli et al., 2012). In Australia, breast cancer is the most frequently diagnosed cancer in women and is the second highest cause of cancer related death (Bech et al., 2012). On average, one in eight women are expected to develop breast cancer in their lifetime (Bech et al., 2012;Yu et al., 2014). The incidence of breast cancer worldwide is increasing annually and it affects both males and females. Breast cancer is, therefore, an important priority area for the Australian health system and is crucial to understand
Many men and women are facing what we call the era of cancer. Cancer is now one of the most deadly diseases in world, without proper treatment, someone can die within just a couple weeks, month or years. Cancer cannot be labelled as one disease because there are many different assortments with this sickness. The world’s oldest documented case of cancer is 3500 years old, it was recorded on a papyrus, documenting eight cases of breast cancer. With this discovery, physicians could all join hand in hand to help find a solution for this disease. Throughout the years of finding, what is now one of the most deadly diseases in the world, doctors and scientist are working day and night around the clock to make sure patients are being