Candesartan Case Study

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3.4.12. RESULTS AND DISCUSSIONS OF CANDESARTAN IN-VIVO STUDY:
3.4.12.1 Estimation of Candesartan pharmacokinetic parameters:
The concentration of Candesartan in plasma of each rat and the respective average values at different time intervals following the oral administration of pure Candesartan, Candesartan conventional capsule dosage form and Candesartan optimized formulation (Run 18) are given in Table 16. A comparative mean plasma concentration-time curve of pure Candesartan, Candesartan conventional capsule dosage form and Candesartan optimized formulation (Run 18) are illustrated in Fig.14. The mean pharmacokinetic parameters of the pure Candesartan, Candesartan conventional capsule dosage form and Candesartan optimized formulation (Run 18) were estimated from the in vivo experiments and the results are shown in the Table17--19 respectively.
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From these results it was observed that the peak plasma concentration values of Candesartan optimized formulation (Run18) was improved enormously when compared with that of pure Candesartan and Candesartan conventional capsule dosage form which indicated SEDDS formulation improves the availability of drug drastically and in turn peak plasma
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