Case Study 8
1. List 6 risk factors for DVT.
Inheriting a blood clot disorder
Prolonged bed rest, such as long hospital stay
Injury or surgery
Pregnancy
Birth control pills or hormone replacement
Being overweight or obese
2. Identify at least 5 problems from L.J.’s history that represent his personal risk factors.
Smoking history
Personal history of DVT
Prolonged bed rest
Age of above 60 years old
Sitting for long period of times (Bus Driving)
3. Something is missing from the scenario. Based on his history, L.J. should have been taking an important medication. What is it, and why should he be taking it?
He should have been taking a blood thinner. This will decrease the blood’s ability to clot. This keeps the existing clots from getting
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“Your physician prefers the injections over the pills.”
d. “The enoxaparin will work to dissolve the blood clot in your leg.”
8. The order for the enoxaparin reads: Enoxaparin 70mg every 12 hours subcutaneous. L.J. is 5ft, 6in. and weighs 156lb. Is this dose appropriate? The dose is appropriate because enoxaparin may be given at rate of 1mg/kg every 12 hours for acute impatient DVT treatment. Pt is 156lb which is approx. 70kg making this his appropriate dose.
9. What special techniques do you use when giving the subcutaneous injection of enoxaparin?
a. Rotate injection sites
b. Give the injection near the umbilicus
c. Expel the bubble from the prefilled syringe before giving the injection
d. After inserting the needle, do not aspirate before giving the injection.
e. Massage the injection site gently after the injection is given.
10. True or False: Enoxaparin dosage is directed by monitoring activated partial thromboplastin time (aPTT) levels. Explain your answer.
While aPTT may be monitored in obese or patients with renal insufficiency, it is not typically necessary for deciding dosages. Instead patient weight typically is used to decide appropriate drug dosing for Enoxaparin.
11. What instructions will you give L.J. about his activity?
He is to be on bed rest with low mobility due to need for elevation of extremities to prevent thrombus from developing into an embolus. Tell him to change positions periodically to
a normal manner and it may take longer to clot. If prescribed this medication they will attend a Anticoaglant
Mary is a 50 year old female admitted with shortness of breath and chest pain that started early this am. She is overweight, takes hormone replacement therapy. Her right lower leg is edematous and is diagnosed with deep vein thrombosis and pulmonary embolus. She is given an infusion of Activase in the emergency room and then started on a heparin drip at 1200 uints per hour intravenously once she arrives to the floor. She is going home on Coumadin . The following are the things I will teach Mary to do or observe while taking Coumadin at home.
Avoidance of other nephrotoxic drugs is equally important; therefore, the other 3 answer choices are incorrect.
When the sign and symptoms of Anaphylaxis noted following vaccination. First and foremost we have to placed the patient flat to promote venous blood return to the heart, then place the patient in left lying position and maintain clear airway if the patient is unconscious (PSA 2014). If patient is conscious put them in supine position with head down and elevate legs. Call for assistance and never leave the patient alone to prevent risk of injury. Dial 000 and book for the ambulance. Without any delay administered Inj. Adrenaline Intramuscular on anterolateral thigh if respiratory or cardiovascular symptoms noted. Adrenaline is life saving drug and it is not for intravenous use (ASCIA 2015). Recommended Adrenaline dose is 0.01ml/kg body weight of adrenaline 1:1000 of maximum 0.5 ml (PSA 2014 and ATGI 2016). Mistakenly administering of Adrenaline won’t do any serious harm. Administration of Adrenaline is the key of anaphylaxis
10 mg four times a day intravenously. On the other hand, it might not be really
Invokana is initially administered 100 mg by mouth every day before the first meal of the day. The dose can be increased to 300 mg every day in patients tolerating the initial dose who have a GFR greater than 60 mL/min/1.73m2 in need of additional glycemic control.3 Adverse effects that have been noted with this medication include increased urination, yeast infections, and negative gastrointestinal effects.4,6 Safety considerations include dehydration, vaginal yeast infections in women and men, and it is not advised to take Invokana if you are allergic or have severe renal impairment and/or are on dialysis.4 It is therefore imperative that patients are screened appropriately before being placed on this medication, and that monitoring is performed in certain disease states, particularly those involving renal disease.
Taking the advisable dosages each few hours will enable you to to continue your day-to-day activities. A heating pad positioned around the region with the organ may also be useful in minimizing the discomfort you happen to be enduring.
“I’ll start him on a small dosage in the morning. I’m going to start him at 5mg, three times a day,” Karl explained. “It should start working in a week or so. If we don’t see improvement than, I’ll double the dosage.”
Therapeutic Dosage; Adult, child over 45 kg:300-600mg/day PO, or 0.4 mg/kg/hr. Child under 45 kg
The enoxaparin dose should be 1 mg/kg twice daily and given subcutaneously, if it is used for this purpose. Bridging will be resumed 24 hours or later after surgery, as well as warfarin and continued until the anticoagulation level (INR) is therapeutic. Once the INR is within desired therapeutic range, it must stay therapeutic for 24 hours before removal.
In known cases of AT III deficiency, administration of AT III concentrate can help achieving the target aPTT levels and reduce heparin use. 1000 international units of AT III concentrate is usually given if ACT is less than 400 seconds despite administration of total dose of 750 units/kg of heparin. Due to AT III high cost, administration of 2-4 units of fresh frozen plasma is another approach in these cases. However, the latter has its own drawback of increased risks associated with blood products
Periodic surveillance and evaluations are to be maintained in order to assess risks, especially during pregnancy. Aside from blood thinners, individuals with Factor V Leiden Mutation may minimize their risk of blood clots by: living a healthy lifestyle, avoiding prolonged periods of immobility, keeps preexisting medical complications under control, and avoid smoking. Anyone who has a family member that has had a DVT or PE that is unexplained, recurrent, or developed in an unusual site may find it beneficial to be tested for factor V
• The physician should start you on the lowest effective dosage if possible, if need be, he increases the dosage gradually as the body become used to the injection, instead
The standard dosage of drospirenone-ethinyl-estradiol has a range of 0.02-0.03 mg of ethyinyl-estradiol and the dosage of drospirenone is consistent at 3 mg (Blode, Kowal, Roth, & Reif, 2012). For this patient, I would prescribe 0.03 mg ethinyl-estradiol/3 mg drospirenone.
Concerning the administered basic therapy, all patients received MTX dose 17.5 mg/week. In addition, patients received hydroxychloroquine