Charles River Laboratories, while now a multinational CRO with sites in over 15 countries, started with humble beginnings as a one man lab founded by Dr. Henry Foster. Initially, Dr. Foster set out to provide the greater Boston area with robert research models that he bred and cared for himself. Now, Charles River Laboratories has well over 8000 employees all over the word, and is dedicated to
Behind the scenes of a lab there is a team of hardworking individuals ensuring that scientific progress can be made. At Charles River Labs in Worcester, MA that team is known as Lab Operations. There are different segments of lab operations, such as sample management, clinical services support, and general lab support. All segments of Lab Operations
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Ammonium hydroxide (H5NO or NH4OH) that has a density of ~0.90 g/cm3. It is a colorless solution made by adding water and ammonia. Instead of adding formic acid, ammonium hydroxide is added into Needle Rinse 1.
Carbamazepine (C15H12N2O), which is a drug that has been used as an anticonvulsant for patients that suffer from seizures or epilepsy, neurological pain, and also to aid in manic and aggressive behavior for people suffering from dementia. At CRL, it is used as an internal stock standard.
Carbutamide (brand name Glucidoral) is another chemical used as an internal stock standard. The drug was initially released to help with diabetes, however it was later taken off the market due to the negative side effects.
Chrysin (C15H10O4) alsa known as 5, 7-Dihydroxyflavone, is also used as an internal stock standard. Chrysin is a flavone, or , that is found in carrots, honeycombs, and the blue passion flower.
Dimethyl sulfoxide, more commonly referred to as DMSO, is an extremely useful chemical as it is a fantastic ‘vehicle’ that penetrates membranes. It is a very polar organic liquid and is used frequently as a solvent. It is used to create the aqueous versions of the internal stock standards.
Formic Acid (HCOOH or CH2O2) is the simplest of carboxylic acids and has a density of 1.22 g/cm3. Formic acid is also found in bites/stings from insects in the Hymenoptera family contain formic acid. Commercially, formic acid is primarily used as a preservative for
The Cu Later lab experiment is designed to allow you to practice lab skills in implementing and performing a series of reactions. Specifically, four types of chemical reactions will occur: oxidation/reduction; double replacement; single replacement; and decomposition. You will begin with a known amount of copper metal, which, after progressing through several steps, is reproduced. In this experiment you will observe and record the various changes such as heat, color changes, and production that occur. This procedure is used to observe some chemical reactions of copper and its compounds while also performing the lab appropriately as to retain the copper as much as
Carbamazepine. Carbamazepine is another anticonvulsant drug that is widely used as a mood stabilizer; however, it is not approved by the FDA as a mood stabilizer (Sinacola & Peters-Strickland, 2012). Common side effects of Carbamazepine include rashes, dizziness, and fatigue. In addition to the other drugs mentioned, carbamazepine also requires testing with its use because it may increase the risk of agranulocytosis. However, it is rare with proper monitoring by the
UCCC is a respectable healthcare facility providing the local community accessible, affordable, quality healthcare. In order to improve UCCC’s image and market share, the following strategies are recommended for the future of the practice.
In order to advance diversity efforts, Northrop Grumman supports a dozen Employee Resource Groups with more than 19,000 employees involved. The groups span a very diverse set of subcultures, including African Americans, Latin Americans, Native Americans, the LGBT community, women, parents, veterans and the disabled. The Employee Resource Groups have defined goals of providing networking, as well as volunteering, opportunities. In fact, anyone can participate in any of the groups if they contribute by volunteering. They are also a resource for mentoring programs and professional development.
Narcolepsy is when patients suddenly and uncontrollably fall asleep. Depressants are also used for anesthesia like benzodiazepines and barbiturates which are effective as sedatives. By depressing brain activity, these depressants are able to help patients fall asleep. Barbiturates can be used to treat sleep disorders, as can benzodiazepines. Because both medications can take hours to get out of the body, however, another class of medications has been developed for the treatment of sleep disorders. Zolpidem and eszopiclone are two different medications that can treat only some of the parts of the brain that respond to benzodiazepines. Depressants can also be used medically as anticonvulsants. Anticonvulsants work to lower the overall activity in the brain, thus helping prevent the abnormal electrical
Benzodiazepines are anxiolytic tranquilizers used for medical conditions such as anxiety, alcohol withdrawal, insomnia, and muscle relaxation. Generalized anxiety disorder, or GAD is one of the most common mental illnesses benzodiazepines are responsible for combating. GAD is a disorder in which a person experiences constant, low-level anxiety (Wesely, 2014, p. 244). They act on the central nervous system as they produce sedation and lower anxiety levels (eMedicine Health). As stated by Yakugaku Zasshi in his journal article, “Benzodiazepines (BZs) work by agonising gamma-aminobutyric acid (GABA) receptor complex and
Möller (1999) has critically examined and analyzed the effectiveness, risk, and safety measures of using benzodiazepine that is consistent with Batelaan, Van Balkom & Stein (2012) idea. Moller (1999) argues that as much as benzodiazepine has many survival values, the drug is crammed with notable side effects and risks that can jeopardize the health of the patient. The author presented traceable basic pharmacotherapy of benzodiazepines that has played an imperative role in accounting the side effects of it. In addition, the author has provided pharmacological properties of benzodiazepines and linked the properties with side effects and potential risks. The author has analyzed the clinical indications and
To a 5 mL conical vial with a spin vane, 5-nitro-2, 3-dihydrophthalazine-1, 4-dione (.151 grams) was added. Next, sodium hydroxide (2 mL, 3M) was added to the conical vial and stirred until a reddish brown color was obtained. The addition of sodium hydrosulfite (.254 grams) followed, and the sides of the conical vial were
Nelson and her colleagues made every effort to utilize their limited research space, but after a while it became clear an expansion was needed, and they moved the Surbeck Laboratory to the California Institute for Quantitative Biosciences (QB3) building in 2005. QB3 is a biotechnology research consortium for UC Berkeley, UC Santa Cruz, and UCSF, housed on the Mission Bay campus in Byers
Sedative-hypnotics, including benzodiazepines, are a group of drugs used to treat the symptoms of anxiety, panic disorders, and insomnia.
In this lab, we examined cubes of phenolphthalein submerged in Sodium hydroxide to see what the effects would be. For the phenolphthalein, we used Agar cubes cut in three different sizes: small, medium and large. The purpose of this Lab was to study the surface area to volume ratio in cells and see how this ratio affects cell size. Phenolphthalein (C20H14O4) is one of the most common acid-base indicators used to determine the end point in acid-base titrations. Sodium hydroxide (NaOH) is an inorganic compound also known as lye.
This process was then repeated two more times with subsequent additions of 10 mL of the 0.5M aqueous NaHCO3 and the aqueous layers drained off into the above mention labeled 100-mL beaker. Finally 5 mL of deionized water was placed into the funnel and mixed. The water was then drained off into the beaker containing the aqueous solution extracts. The solution was then saved until need later in the experiment.
Companies strive to choose not only the best marketing channels, but also the best profitable channel. A profitable channel can promote and successfully sell out of a product that might not otherwise turn a profit for their producers (New Charter University 2015). “The calculations from the cost accountant for the retail segment accounts were 60 percent of sales, and for the foodservice segment accounts were 40 percent. The cost accountant believes that both channels are profitable. The accountant also believes that the company achieves an overall average gross margin of 60 percent on its sales (Bowersox, D. J., Closs, D. J., Cooper, M. B.,
Dry Force Corp. is a full-service water damage restoration service company that is located in Irving, Texas. This water damage restoration company was established in 2003. Dry Force Corp. is a one stop shop. Their services include flood damage, burst pipes, overflowing toilets, sewer backups, floor drying, storms and floods, crawlspace drying, fire damage, and remodels. Dry Force Corp. directly works with all the insurance companies on behalf of their customers. 100% financing is available here. Dry Force Corp. renders a 1 hour response time. Dry Force Corp. is ready to help their patrons 24 hours a day, 7 days a week, 365 days a year. This water damage restoration company offers a 24/7 free evaluation. Dry Force Corp. is certified by the Institute
Accenture Duck Creek with a “pay as you grow” Pricing model, offers out-of-the-box templates and integration accelerator to minimize pricier custom development and maintenance i.e. dependency of insurers on Accenture for future developments.