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Case Study : Charles River Laboratories

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Charles River Laboratories, while now a multinational CRO with sites in over 15 countries, started with humble beginnings as a one man lab founded by Dr. Henry Foster. Initially, Dr. Foster set out to provide the greater Boston area with robert research models that he bred and cared for himself. Now, Charles River Laboratories has well over 8000 employees all over the word, and is dedicated to
Behind the scenes of a lab there is a team of hardworking individuals ensuring that scientific progress can be made. At Charles River Labs in Worcester, MA that team is known as Lab Operations. There are different segments of lab operations, such as sample management, clinical services support, and general lab support. All segments of Lab Operations …show more content…

Ammonium hydroxide (H5NO or NH4OH) that has a density of ~0.90 g/cm3. It is a colorless solution made by adding water and ammonia. Instead of adding formic acid, ammonium hydroxide is added into Needle Rinse 1.
Carbamazepine (C15H12N2O), which is a drug that has been used as an anticonvulsant for patients that suffer from seizures or epilepsy, neurological pain, and also to aid in manic and aggressive behavior for people suffering from dementia. At CRL, it is used as an internal stock standard.
Carbutamide (brand name Glucidoral) is another chemical used as an internal stock standard. The drug was initially released to help with diabetes, however it was later taken off the market due to the negative side effects.
Chrysin (C15H10O4) alsa known as 5, 7-Dihydroxyflavone, is also used as an internal stock standard. Chrysin is a flavone, or , that is found in carrots, honeycombs, and the blue passion flower.
Dimethyl sulfoxide, more commonly referred to as DMSO, is an extremely useful chemical as it is a fantastic ‘vehicle’ that penetrates membranes. It is a very polar organic liquid and is used frequently as a solvent. It is used to create the aqueous versions of the internal stock standards.
Formic Acid (HCOOH or CH2O2) is the simplest of carboxylic acids and has a density of 1.22 g/cm3. Formic acid is also found in bites/stings from insects in the Hymenoptera family contain formic acid. Commercially, formic acid is primarily used as a preservative for

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