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Causes Of Transfusion Related Lung Injury

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Transfusion related lung injury is a form of acute lung injury and is an important cause of transfusion-associated morbidity and mortality. A Transfusion Related Lung Injury (TRALI) is defined as an acute lung injury with hypoxemia and PaO2/FiO2 less than or equal to 300 or SpO2 less than 90 percent on room air, presence of bilateral pulmonary edema with no evidence of left atrial hypertension, no preexisting lung injury before transfusion, onset of symptoms within six hours of transfusion and no temporal relationship to an alternative risk factor for acute lung injury. The transfusion related lung injury is mostly transient and will improve within 48 to 96 hours. Unlike other transfusion related circulatory overload, TRALI is non cardiogenic
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