Chronic Disease: Sickle Cell Anemia

Sickle Cell anemia is a group of inherited red blood cell disorders, or a collection of recessive genetic disorders characterized by a hemoglobin variant called Hb S. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. There is a substance in the red cell called hemoglobin that carries oxygen inside the cell. One little change in this substance causes the hemoglobin to form long hard rods in the red cell when it gives

In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid "sickle" shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking to form a helical shape. Once this happens the cells cluster together and elongate and the cells start to "sickle". A person who has sickle cell anemia can only get it if both of their parents carry the sickle cell trait, if only one parent has the trait then there children are at risk for having the trait.

Sickle cell anemia is an anemia that is inherited and mostly affects people whose heritage can be traced back to places where malaria was prevalent. There are approximately 100,000 Americans that have the disease and many more with the trait. Several of my family members are afflicted by this medical condition that causes red blood cells to take on an irregular shape.

Sickle cell disease is an inherited form of anemia. This means both parents must pass on the defective gene for a child to be affected. The gene is more common in families that come from Saudi Arabia, Africa, Mediterranean countries, India, the Caribbean islands, and North, South, and Central America of African descent.

Sickle cell anemia (SCA) is an autosomal recessive genetic disorder. This missense mutation is characterized by mutant beta globin subunits that tend to stick together (Cummings, 2014). As a result, abnormally shaped red blood cells are produced by this disorder. The erythrocytes are sickle or crescent shaped. Sickling occurs under hypoxic conditions, in which there is insufficient supply of oxygen delivered throughout the body (Sun & Xia, 2013). In order to inherit this monogenic disease, one copy of the sickle globin gene from each parent must be passed on to the offspring (Ashley-Koch,

Sickle cell is a blood disease. People with sickle cell anemia have crescent moon shaped blood cells that are hard and sticky. When the Sickle cells move through blood tubes, they can clog blood flow and break apart. This can cause main, damage, and a low blood count. The symptoms of the disease are not life threatening, however are not enjoyable. Sickle cell anemia can cause you to experience dizziness, headaches, and shortness of breath. Your skin may also turn more yellow or pale than it usually is. Sickle cell is an inherited disease. It is an unpreventable disease that you are born with. If you have a sickle cell gene, you do not have sickle cell, however your children have a 25% chance of having sickle cell anemia. This blood disorder can cause pain and discomfort but it is unlikely that your life will be in danger if you have the disease.

Sickle Cell Anemia is a genetic disorder dealing with the hemoglobin within the red blood cells the individual has hemoglobin S (1). This causes the red blood cell to become gelatinous when deoxygenated (2).

So what exactly is Sickle Cell Anemia? Sickle cell is an inherited blood disorder that affects red blood cells due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Sickle cell has a lot to do with natural selection and is known as genetic disorder. You may never know who will have it in your family. It will not affect everybody. Sickle cell effect the red blood cells in your body. The red blood cells in your body begin to become deformed. They begin to look, “crescent shaped and have difficulty passing through small blood vessels, which could slow or block blood flow and oxygen to parts of the body.” The cresset shaped is where sickle cell gets its name from. When sickle cell mutates in your body, it begins to effect the muscles and even could possible effect the oxygen flow into your body. When the oxygen is blocked, this causes pain and even harm to your organs and even muscles. When this happen, this effects a person ability to be active. According to web MD, “Severe pain is an emergency called acute sickle cell crisis. A person may not know what brought on the pain, but infection and dehydration are common triggers.”

Imagine having to deal with Sickle Cell Anemia on a daily basis. Having to be at doctors more than now. Sickle Cell Anemia is a disease that African Americans can inherit. Sickle Cell is a group of disorders that cause red blood cells to become misshapen and break down. There are many complications people can suffer from when they have sickle cell.

Sickle cell disease is a hereditary blood disorder caused by an abnormal hemoglobin in the red blood cell. Hemoglobin is a type of protein that carries oxygen in the body. In order for someone to have sickle cell disease they would need to have been passed down from at each one of their parents, by inheriting a total of two hemoglobin genes. The fact that this is a hereditary disease means that it is not considered to be contagious. This disease comes in about six different forms, but the most severe of them all is sickle cell anemia. Sickle cell is an inherited disease that affects the red blood cells causing debilitating symptoms, however, with treatment people with this disease can quite possibly live an otherwise

Sickle Cell Disease is an autosomal recessive genetic disease that occurs due to a mutation in the β-globin gene of hemoglobin. Autosomal meaning that it is not linked to a sex chromosome, so either parent can pass on the gene to their child. This mutation is a result of a single substitution of amino acids, Glutamic for Valine at position 6 of a β globin chain. The presence of this mutation causes

Sickle Cell Anemia is a group of disorders that cause red blood cells to become misshapen and break down. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Ashley-Koch, Yang and Olney). Sickle Cell Anemia causes your red blood cells to be thin, stiff, and shaped like a sickle. But your red blood cells are supposed to be round and soft. A person that is diagnosed with sickle cell anemia, their blood cells start to become clogged, causing blood clots, which can cause a great amount of health issues including: infections, stroke, and acute chest syndrome. People get sickle cell anemia by inheriting a mutated gene from both of their parents. On the down side, there is not currently an effective cure for sickle cell anemia, there are several different therapeutic approaches to treating and attempting to cure the disease and help people who are affected with sickle cell anemia better manage their symptoms. There have also been several great scientists that dedicated a lot of research to help find a cure for sickle cell anemia.

Sickle cell disease is the group of inherited disorder of the red blood cells that is characterize by abnormal hemoglobin. The red blood cells in sickle cell disease are rigid and sickle shape. Many complications arise due to the sickle shaped cells because these cells are not flexible as compare to normal red blood cells and and causes destruction and blockage of red blood flow. The most common form of sickle cell disease is autosomal recessive disorder is sickle cell anemia.

I believe that you have come across this health condition -sickle cell disease (SCD). It's a serious type of blood disorder commonly known as sickle cell anemia. At first I thought it a rare condition but nowadays there are an increasingly high number of people suffering from the same. Sickle cell anemia is a hereditary condition in which the patient's body does not have enough healthy blood cells to carry oxygen around the body. The red blood cells assume an irregular shape of that resembles a sickle or the crescent moon. This makes the sickled cells to get stuck in the blood vessels causing blockage of the flow of blood and oxygen. This condition is mostly diagnosed during infancy that is around 5-6 months though it may arise at as later

Sickle cell anaemia Sickle cell anaemia is just one genotype of sickle cell disease(1). Sickle cell disease is the collective term used for a group of hereditary conditions, which share two main characteristics – sickle shaped erythrocytes in the blood and the development of disease on account of those sickle cells(1,2). Sickle cell disease affects multiple systems in the body and causes episodes of acute illness and end organ damage(1). Sickle cell anaemia occurs as a result of a homozygous βs allele and is the more prevalent form of sickle cell disease in the world, accounting for 70% of cases of sickle cell disease in African populations(1). Pathophysiology Sickle cells are caused by a mutation in the β-globin gene, which causes polymerization and results in morphological elongation, sickling(2) and results in an erythrocyte with a disrupted architecture, alterated flexibility and promotes cellular dehydration with physical and oxidative cellular stress and haemolysis(1).