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Cigarette Smoke Toxins Deposited On Surfaces : Implications For Human Health

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Cigarette Smoke Toxins Deposited on Surfaces: Implications for Human Health
Lily Lee, Lynn Mercredi, Rebecca Sklaren

Manuela Martins-Green, Neema Adhami, Michael Frankos, Mathew Valdez, Benjamin Goodwin, Julia Lyubovitsky, Sandeep Dhall, Monika Garcia, Ivie Egiebor , Bethanne Martinez, Harry W. Green, Christopher Havel, Lisa Yu, Sandy Liles, Georg Matt, Hugo Destaillats, Mohammed Sleiman, Laura A. Gundel, Neal Benowitz, Peyton Jacob III, Melbourne Hovell, Jonathan P. Winickoff, Margarita Curras-Collazo

ABSTRACT
Cigarette smoking is one of the greatest health risks to the human population. Toxic to both smokers and nonsmokers, smoking has developed a new threat, thirdhand smoke (THS), which is the accumulation of secondhand smoke (SHS) on surfaces, becoming more toxic as it ages over time. This study attempts to study the threat of THS on children and others in environments where smoking has occurred by investigating the effects of THS on liver and lung function, skin healing, and behavior in mice exposed to THS under conditions similar to human exposure. The exposed mice excreted levels of NNAL similar to those found in children exposed to SHS. In liver, THS increased lipid levels and resulted in non-alcoholic fatty disease. In lungs, it stimulated high levels of inflammatory cytokines, possible precursors to fibrosis, asthma, and chronic obstructive pulmonary disease. THS exposed mice exhibited poor healing capabilities were hyperactive. These results and implications

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