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Clinical Trial Entries Essay

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Do Primary Researchers Register their Studies in Clinical Trials Registries? INTRODUCTION When addiction research first began in the 1930’s the common misconception was that addiction was a byproduct of immorality or from a deficit in willpower. This misconception largely shaped therapies to treat addiction. Early therapies focused on punishment rather than treatment and prevention. However, this misconception has largely changed in modern time thanks largely to the greater emphasis on a systematic scientific approach in medical research. This has led to greater improvements in the care of those suffering from addiction(1). In order to continue this increasing advancement in the treatment of addiction, medical research will also have to continue to improve and refine its methods and address concerns that might affect its findings. …show more content…

Publication bias is defined by Dickersin as “the tendency on the parts of investigator, reviewers, and editors to submit or accept manuscripts for publication based on the strength of the study findings” (Dickersin,1990). Clinical trial registration has been proposed to help resolve these concerns (Dickersin & Min, 1993) and also help improve both the transparency and credibility of clinical research. This can be accomplished by using registries to learn not only about studies that are published but also about studies that have been conducted but not published. Additionally by maintaining a public record of the intended apriori primary outcomes, registration of trials can help to combat the problem of authors changing the primary outcome post hoc to report an outcome that has a statistically significant difference. (Dickersin & Rennie,2003, Jones CW & Platts-Mills, 2012, Chan et al, 2004, Dwan et al,

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