Do Primary Researchers Register their Studies in Clinical Trials Registries? INTRODUCTION When addiction research first began in the 1930’s the common misconception was that addiction was a byproduct of immorality or from a deficit in willpower. This misconception largely shaped therapies to treat addiction. Early therapies focused on punishment rather than treatment and prevention. However, this misconception has largely changed in modern time thanks largely to the greater emphasis on a systematic scientific approach in medical research. This has led to greater improvements in the care of those suffering from addiction(1). In order to continue this increasing advancement in the treatment of addiction, medical research will also have to continue to improve and refine its methods and address concerns that might affect its findings. …show more content…
Publication bias is defined by Dickersin as “the tendency on the parts of investigator, reviewers, and editors to submit or accept manuscripts for publication based on the strength of the study findings” (Dickersin,1990). Clinical trial registration has been proposed to help resolve these concerns (Dickersin & Min, 1993) and also help improve both the transparency and credibility of clinical research. This can be accomplished by using registries to learn not only about studies that are published but also about studies that have been conducted but not published. Additionally by maintaining a public record of the intended apriori primary outcomes, registration of trials can help to combat the problem of authors changing the primary outcome post hoc to report an outcome that has a statistically significant difference. (Dickersin & Rennie,2003, Jones CW & Platts-Mills, 2012, Chan et al, 2004, Dwan et al,
It is believed that certain individuals are predisposed or vulnerable to addiction based on biological, psychological and social influences. The euphoric high produced by many addictive substances is the result of overstimulation of the “pleasure center” of the brain. This is the same area that controls emotions, fear, self-control and overall feelings of wellness. The presence of these foreign chemicals creates a response that the brain will crave as soon as it fades. The brain’s chemistry works against its own health, as it rewires its decision making faculties around the primary goal of finding and taking more of the drug” (1). Many people mistakenly believe that psychological addiction is somehow less serious or real than physical addiction. The psychological aspects of addiction are much more challenging to repair and recover from than the physical addiction. Psychological addiction can last for years or even a lifetime.
A broad range of medical and psychological therapies is currently available for people who struggle with substance addictions. The scientific community is working on evaluation of various treatments to determine which strategies offer the best chances of successful outcome. People who need treatment for alcoholism and drug use are very diverse group. Addiction is a disorder that requires an individual case approach; therefore, different ways to
The definition provided above is accessible and easy to understand; however, it initiates false beliefs among individuals because it fails to acknowledge that drug addiction is a mental health problem. Moreover, when words such as, “dependence”, “control” and “craving” are used to define drug addiction, it leaves an impression to the reader that addicts are indeed “people who cannot control their impulses.” Consequently, when we fail to recognize that drug addiction is a mental health problem, our focus is diverted towards the physical aspect of drug addiction. This could cause the belief among individuals that drugs alone cause the addiction. It is essential to acknowledge that there are chemical hooks in drugs; however, individuals need to understand that drugs alone do not cause the addiction. We need to identify and distinguish the “root cause” of addiction and ask ourselves: what caused the individual to take the drug in the first place?
Some individuals may dislike the term ‘addiction’ in relation to drugs or other substances, particularly as it infers that a person is powerless over their use of a particular drug or in some circumstances, a number of substances. Whilst others maintain it is this powerlessness that is the foundation of diagnosis and treatment – that treatment is not possible without recognition of addiction itself as the ‘problem’ being
As the disease model argues that there is no cure for addiction, the only treatments available aims to reduce or suppress the urge to use drugs (McNeece & DiNitto, 2012). Firstly, addicts
You likely purchased this book because you or someone you care about is struggling with addiction. I suspect you are searching for help but don’t know where to find guidance based on reliable scientific principles. The information in this book will provide that guidance.
Prescription medications are intended to help individuals not create new problems. When an individual is diagnosed with ADHD they often seek medical attention. Medication will often be prescribed to help this individual manage their ADHD symptoms. However, many of the medications used to treat ADHD are stimulants. These stimulants can have adverse effects on the human body. There are hidden dangers when using ADHD medications such as side effects, addiction, and classification.
Addiction treatment is a complex and paradoxical issue. Despite the fact that most of the medical and academic institutions define addiction as a chronic brain disease, it is too often treated on an acute basis. Chronic conditions are defined by the World Health Organization (WHO) as requiring ongoing management over a period of years or decades and cover a wide range of health problems. The goals of chronic care are not to cure, but to enhance functional status, minimize distressing symptoms, prolong life through secondary prevention and enhance quality of life.
In 1960 E.M. Jellinek a scientist, was credited for introducing this controversial and initially popular model of addiction from past research of the late 1930`s and early 1940`s. His findings have received wide acceptance however, the research from which he
People with addictions can have a very difficult time overcoming them. While pharmacological methods have been effective, it is worth it to do research and see if nonpharmacological methods can be more effective. The science of
The involvement of professional medical writers in developing peer-reviewed publications reporting clinical trials has been a matter of debate in the last decade. It has been criticised by some (1 Sismondo S. (2009),2) but defended by others (3,4).
Through my search for articles I discovered that there were no studies of randomized controlled trials, and there were therefore no systematic reviews or Meta analyses of randomized controlled trials related to my topic question. This limited the variety and amount of studies that could be utilized to help answer my question.
Results: After review of articles, six met criteria. Two of them were random control trials with the remaining four being observational studies. The random control trials focused on individuals’ response to treatment, and measured the cure and completion rates.
Despite an increasing number of sound reasons support the involvement of PMWs in the publication of clinical trial data in peer-reviewed journals (REF), few data show what value corresponding authors place on PMWs. Our short online survey gathered perspectives of corresponding authors both with and without PMW working experience. Our survey aimed to assess their opinion and gain insight into their understanding of PMW assistance in several steps of the publication process. Our target population was 240 corresponding authors from different part of the world. In contrast with a previous survey, published in 2014 by Marchington and colleagues and limited to corresponding authors in contact with one specific medcomms, we selected our authors
& Folkers, K.M. (2017, December 7). A Clinical Trial By Any Other Name… [Web log post]. Retrieved from https://cedriccracraft.wordpress.com/2017/12/07/a-clinical-trial-by-any-other-name/