Cystic Disorders: Cystic Fibrosis

Cystic Fibrosis (CF) is an autosomal recessive genetic disease that causes thickened mucus to form in the lungs, pancreas, and other organs. It affects a specific protein called Cystic Fibrosis Transmembrane Regulator (CFTR) that controls the normal movement of sodium, chloride, and water in and out of the cells within the body. Those diagnosed with CF have either too little or abnormal CFTR. When CFTR is absent or defective, the mucus usually secreted by the cells in the pulmonary airways, pancreatic ducts, and gastrointestinal tract become thickened, leading to obstructions, frequent infection, and loss of function in the affected organs (Cystic Fibrosis Symptoms, Causes & Risk Factors, 2018). According to the Cystic Fibrosis Foundation

A widely accepted Caucasian disease has since changed; as cases of its existence are appearing in the South Asian Population (Orenstein, Rosenstein and Stern, 2000). First discovered in 1989, Cystic Fibrosis (CF) is a genetically predetermined condition, its presences is lifelong and highly complex, which is why many CF sufferers and families develop various mechanisms in order to adapt to the condition (Tippingemail, Scholes, Cox, 2010). Cystic Fibrosis causes the body to develop thick, sticky mucus which clogs the lungs and affects other organs in the body, mainly the pancreas. The layer of mucus if untreated develops in to a chronic infection which can be detrimental. The pancreas of a CF patient is most vulnerable, once the mucus has

“About 1 in 4,000 children in the United States are born with CF” (Crosta, 2009) and “one in every 3,600 children born in Canada [have] cystic fibrosis” ("Cystic fibrosis Canada," 2011). According to several resources a consensus has formed which proposes that people with northern European ancestry, specifically those that are white, are more likely to be carriers of the disease and thus more at risk of having children with the mutated gene. This risk is even more likely if the other parent of the child is a carrier. Another risk factor for CF is “family history, since the disease is hereditary it increases they likely hood of

Cystic fibrosis is an autosomal recessive disorder due to a defect in the cystic fibrosis transmembrane receptor, protein buildup causing thick mucus and secretions in lungs, pancreas, liver & intestines. The clinical manifestations include respiratory with recurrent lung infections (S. aureus, Pseudomonas), productive cough, dyspnea, chest pain, wheezing, the gastrointestinal with meconium ileus at birth, later failure to thrive, chronic diarrhea, systemic with infertility and heart exhaustion. Obstructive Lung disease, pancreatic insufficiency, elevated chloride in sweat diagnostic will lead to a bronchiectasis, infertility, growth delays and Meconium Ileus (MC initial presentation)

According to Grossman (2005), Cystic Fibrosis also Known as “CF”, is a genetic or an inherited disorder develop due to a defect of cell protein function. An individual can inherit Cystic Fibrosis only when both parents meaning both the person’s father and mother are carriers of this dysfunctional gene. The abnormal cell protein that causes Cystic Fibrosis is known as CFTR or cystic fibrosis transmembrane regulator. This particular type of cell protein helps maintain a balanced movement of certain form of salt and water in the body’s cell. In Cystic Fibrosis, this movement of salt and water in and out of the body cells become impaired leading to a thickened mucus. The Cystic Fibrosis Foundation point out on his website that both boys and

Cystic Fibrosis causes mucus to become thick and sticky building up in the lungs and blocking airways. The buildup of mucus makes it easy for bacteria to grow leading to repeated lung infections. Cystic fibrosis also blocks the pancreas as the digestive enzymes that the pancreas makes can't reach the small intestine to help break down food. This can cause vitamin deficiency and malnutrition due to the nutrients not getting used. Cystic Fibrosis also causes the sweat to become very salty and results in large amounts of salt loss. This can upset the balance of electrolytes in your body and cause many health problems. If a genetic test or blood test suggests CF, a sweat test with high levels of salt can confirm the

Cystic fibrosis also known as CF is a rare life threatening genetic disorder. CF causes individuals with this disorder to have persistent lung infections, in turn limiting their breathing. Individuals with cystic fibrosis, have a mutated gene that causes a thick, build-up of mucus in the lungs. Generally, it affects many of the body’s organ systems and is only found in about 200,000 people per year in the United States. Cystic fibrosis is the most widely recognized, life-shortening hereditary sickness in Caucasians. It influences the vehicle of salt and water crosswise over cells and influences distinctive organs, yet lung infection is in charge of the dominant part of manifestations, weight of care, and lost years of life. The quality that causes the sickness has now been recognized and sequenced. (Junge et al., 2016)

Cystic fibrosis is a disorder affecting approximately 30,000 U.S. citizens. Although this genetic disorder can affect anyone, whites tend to be at a greater risk of developing this disease. Also males and females seem to have an equal risk of developing cystic fibrosis (Gardner, 2007). Cystic fibrosis is passed onto offspring by a recessive mode of inheritance. After extensive analysis it is believed that there is a single cystic fibrosis locus located on human chromosome seven. Considering a multitude of data and factors such as tissue specificity and the predicted properties of the Cystic Fibrosis Transmembrane Conductance Regulator(CFTR) protein, it is theorized that CFTR is the direct cause of cystic

Cystic fibrosis is the most common lethal genetic disease that affects children and young adults. The disease is inherited and mainly affects the lungs and the digestive system. It is estimated that there is one case of cystic fibrosis in the country in every 3,600 children. More than 4,100 children and young adults suffering from cystic fibrosis attend specialized cystic fibrosis clinics (Horsley, Cunningham, & Innes, 2015).

Cystic Fibrosis is the most common disease of the white population of the United States; however, Cystic Fibrosis is less common in other ethnic groups. It is the most common genetically inherited disease that occurs in about 1 in 2,500 to 3,500 of white newborns. In African Americans, 1 in 17,000 is affected by this disease and only 1 in 31,000 of Asian Americans are affected. People with Cystic Fibrosis have inherited two copies of the defective gene, meaning one copy from each parent is inherited to the child. Both parents must have at least one copy of the defective gene and they are called carriers. Carriers are not considered to have the disease and they do not express any type of symptoms or conditions.

Cystic Fibrosis is a recessive disorder that is a life threatening disease that causes persistent lung infections and progressively limits the ability to breath. Unfortunately, there is no cure for this genetic disorder, but Airway Clearance, Inhaled Medicines, and Pancreatic enzyme supplements can increase the person’s lifespan incredibly. There are about 70,000 people worldwide with this disease. Approximately 1,000 new cases of cystic fibrosis are diagnosed each year. The average human with cystic fibrosis lives to about 30 if they take their medicine.

Cystic fibroses (CF) is a genetically inherited disease that is caused by a recessive allele and has to be inherited from both parents. The gene can lie dormant in both parents and they can live perfectly healthy lives however as they carry the gene it means there is a risk of it being passed onto the child. One in 25 of us carries the faulty gene that causes it (CF trust , n.d.) not many people are aware that they even carry the gene as it is only able to affect an individual if they have 2 recessive alleles of the gene. The defective gene affects the body’s ability to transfer water and salt to and from cells that produce sweat, mucus, and digestive enzymes (Alma, 2016) this means CF suffers produce a very thick sticky mucus that covers the

Cystic fibrosis is a disease in which mucus blocks the airways in the lungs. This causes lung infections over time and limits patients to breathe for a significant amount time. As the infections progress, this can eventually lead to respiratory failure. The mucus stop the pancreas from releasing digestive enzymes and prevents the body from breaking down nutrients. As this is a genetic disease, patients usually inherit two genes of cystic fibrosis. Carriers with one copy of cystic fibrosis do not inherit the disease. Patients that have CF has an abundant amount of bacteria within the lungs. The mucus can affect much more than the lungs and pancreas. For example, mucus can wedge the bile duct and cause liver disease. Even with men diagnosed

Cystic Fibrosis is the leading autosomal recessive disease in people who are Caucasian.  In fact, one in twenty caucasians are a carrier of the disease.  It is a progressive disease that often causes relentless lung infections along with other complications, and these limit the patient’s ability to breathe overtime.  To this day, there still isn’t a cure for Cystic Fibrosis, which is commonly referred to as CF.  The average life expectancy for a person with CF is 40 years old.  This is a great improvement from when the disease was first discovered in 1930, but is still a young age.  In this paper we will review the biological causes of Cystic Fibrosis and the current treatments that are in place, as well as propose a cure.

While cystic fibrosis (CF) is not a new disease, there is still a lot to learn about it. In 1938 a pathologist, Dr Dorothy Andersen, provided the first clear description of cystic fibrosis. Before this time there had been reports of people that had the symptoms of someone with CF. During the seventeenth century children with the symptoms of CF were thought to be bewitched and their life expectancy was very short. Dr Dorothy Andersen gave this disease its name because cystic fibrosis refers to the scarring that is found on the pancreas. People with CF also have associated diseases like salt-loss syndrome, obstructive azoospermia, and gastrointestinal abnormalities. CF is inherited from one’s parents, making it a genetic disease. CF is