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Dendrimers Research Paper

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Dendrimers

Dendrimers are 3D polymers with spherical, highly branched structures. Polyesters, polyamines, and polyamides are commonly used; however, polyamidoamine (PAMAM) dendrimers are the most frequently used due to their high transfection efficiency. The transfection efficiency is highly influenced by the size of dendrimers and the type of amine groups that they are composed of. The primary amine groups participate in DNA binding, so they promote DNA cellular uptake. However, the tertiary amino groups reinforce the release of DNA into the cytoplasm because they act as a proto-sponge in endosomes. Transfection efficiency can be enhanced by increasing the size and diameter of the dendrimers. One example of dendrimer DNA complexes is nitrogen-core

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