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Dequalinium Research Paper

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Dequalinium (DQA) is a dicationic amphiphilic compound that self-assembles and forms vesicle-like aggregates of diameters between 70 and 700 nm upon sonication; known as DQAsomes(33). Owing to their positive charge and mitochondriotropic properties, DQAsomes could bind or entrap various drugs and DNA and transport them to mitochondria(41). A strong interaction was demonstrated between DQAsomes and plasmid DNA(57), in addition, the formed complex effectively protects DNA from digestion by nucleases(58). Moreover, it was demonstrated that DQAsome complexes with DNA can enter cells, approach mitochondria and release the bound DNA after interaction with the mitochondrial membrane(59). Weissig et al demonstrated that DNA complexed with DQA formed
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