Georgiette Oduro-Boateng
Immunology (BIO 3301)
Writing Assignment 1
3/4/15
Differences between human and mice immunology
Stage 1
The American Association of Immunologists was established in 1913. This professional society consists of professional trained distinguished scientists around the globe who are in association with a goal of progressing the understanding of immunology worldwide. AAI provides it members with relevant information, great educational opportunities, etc. The Journal of Immunology is a credible source of information about scientific research because it is the leading and most highly cited journal in the immunological field. The journal also provides peer-reviewed findings on experimental immunology.
Stage 2
Why the
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905037/
• IFN: Stands for Interferon. According to Owen et al. (Immunology textbook), interferons are glycoprotein cytokines produced and secreted by certain cells that induce an antiviral state in other cells and also help to regulate the immune response. In other words, they are group of proteins that inhibit viral infections.
• LPS: Abbreviation for Lipopolysaccharide, it activates many clones of murine B cells to induce their differentiation and division into antibody-producing plasma cells (Owen et al.)
• IL: Abbreviation for interleukins, a group of cytokines secreted by leukocytes, they mostly affect the growth and differentiation of various hematopoietic and immune system cells. (Owen et al.)
• CMV: According to Mayoclinic.org, CMV stands for cytomegalovirus, a common virus that affects practically anyone and hardly causes symptoms. Once a person is infected, the body maintains the virus for life. http://www.mayoclinic.org/diseases-conditions/cmv/basics/definition/con-20029514 • λ5: Lambda 5 is a polypeptide that associates with Vpre-B to form the surrogate light chain of the pre B-cell receptor (Owen et al.).
• Ly49: According to Owen et al., Ly49
IgA – antibodies that are secreted across mucus layer to prevent microbes from penetrating cell bodies
This is immunity in an organism that’s a result from the production of antibodies or lymphocytes after an antigen is identified in the body.
4. Complement (p.458)(complement system): Set of serum proteins designated numerically according to their order of discovery
The human immune system creates a series of responses in the body to defend the body. If a foreign organism, such as a virus or a cold invades your body, it recognizes these foreign organisms, and, in turn, attacks them to get rid of them. One can think of the immune system as an army of many cells which have set up their own bastion in the human body. They have only one job: To defend. The immune system’s cells are various kinds of white blood cells. The human body typically creates about 1000 million white blood cells on a daily basis. A group of these cells, macrophages, establish a patrol of sorts throughout the body killing germs as soon as they enter the body. However, sometimes an infection can cause the macrophages to succumb to it. The body begins to fight back with stronger T- and B-cells.
Lymphocytes are vital to the human body to protect us against disease and initiate an immune response. Each person possesses billions of lymphocytes which collectively provide an individual with the ability to respond to a huge variety of antigens. The wide
The proper functioning of the IL2RG gene is vital for the continuous development of immune cells, specifically the T cells and B cells mentioned above. (Cavazzana et al. 2016)
cells, one including T cells (which play a large role in the body’s immune response by secreting antibodies and other cells). Anti-inflammatory cytokines is the ability of the cytokine to inhibit the synthesis of tumor necrosis factor and other major pro-inflammatory cytokines.
Interferons (IFNs) are substances secreted by cells invaded by viruses that stimulate neighboring cells to produce proteins that help them defend against the viruses. Certain IFNs (such as gamma‐IFN) also amplify the activity of macrophages and NK cells.
These B-cells, after having been phenotyped, are found to express a cell surface marker known as CD11c. While these cells have been labeled, it has yet to be determined what B-cell lineage is giving rise to these memory cells.
Blood-creating stem cells, or haematopoietic stem cells are the basis of the immune system. They are responsible for turning themselves into different types of blood cells, like Red Blood Cells.
The consequence of these interactions is an adaptive immune response of antigen-specific lymphocytes to the antigen, as well as the development of immunological memory. Adaptive immune responses are generated by clonal selection of lymphocytes, and are distinct from innate responses. The immune response consequence is in result to the antigen
caused both by the increase in cytokine secretion and by the decrease in the average death rate of T cells, thereby improving the efficiency of the immune responses \cite{PBFO2010ECMTB, BFOP2011Trans, BFOP2011Bystander}. The results presented here deepen our results in \cite{BOP2006, PBFO2010ECMTB, BFOP2011Trans, BFOP2011Bystander, BOPS2008, BOPF2011Dynamics, OFBP2014Approx}.
An infection is the invasion of the body microorganisms with pathogenic abilities such as bacteria, parasites and Viruses. Pathogens (Bacteria) invade the host cells, multiply greatly and secrete toxins that cause cellular damage or lysis that trigger an immune response that causes localised inflammation and activation of leukocytes to prevent the spread of pathogens to other areas of the body. Depending on the host’s immune system, sometimes the increase in the number of bacteria overwhelms the immune system causing the infection to spread to other parts of the body (Remick, Pathophysiology of sepsis, 2007). This is commonly attributed to gram positive and gram negative bacteria that usually cause severe infections that lead to an extreme inflammatory and immune response as a lot of cytokines are released as the
When the body becomes infected with an illness, it relies on the immune system to fight the illness by allowing white blood cells to begin producing proteins, called antibodies. Antibodies then create a counter offense to decimate the infectious germ that has most likely already caused the body to have symptoms of the illness. The antibodies and immune system then work together to eliminate the virus and help heal the body. Consequently, these antibodies don’t leave the body, they lurk within the bloodstream on the look-out for other invaders, no matter the amount of time it takes for the body to become infected once again. Antibodies are specific to which the virus they are trying to eliminate. For example, an antibody that exterminates
Introduction : B lymphocytes are the effectors of humoral immunity and provides defense against pathogens by producing antibody. B cells constitute approximately 15% of peripheral blood leukocytes and arise from progenitors and precursors in the bone marrow. B lymphocytes undergo random immunoglobulin variable gene rearrangements at the heavy and light chain loci. These chains pair with the Igα and Igβ polypeptides to form the mature B-cell receptor which is then transported onto the cell surface where it can bind antigen and signal inside the cell. Different populations of B cells result in pre immune pools where each cell in these quiescent populations expresses a B cell antigen receptor with a unique specificity. The BCRs come in contact with their specific antigen and generate several intracellular signals are which leads activation, differentiation, and formation of plasma cells and memory B cells. This process mediates the response to subsequent antigen challenges. B lymphocytes play an essential role by not only producing antibodies but also functioning as antigen-presenting cells and certain B cells can also negatively regulate the immune response by producing regulatory cytokines and directly interacting with pathogenic T cells via cell to cell contact. Newly generated immature B cells are selected to enter the peripheral mature B-cell pool only if they do not bind to self-antigen. Immature B cells that bind to self antigen are not generally recruited to mature