Dysthymic Disorder (DD) is a chronic, debilitating depressive illness characterized by depressed mood for 2 or more years1. Pathophysiology of DD, however, remains poorly understood as few studies have assessed brain abnormalities in DD. Patients with DD have symptoms that fall along a continuous spectrum for unipolar depression and respond similarly to medication2 as those with Major Depressive Disorder (MDD); therefore, abnormalities in brain structure, function, and metabolism in DD previously have been inferred from those in MDD. Brain metabolism and how it is altered in illness can be quantitatively assessed in vivo using Magnetic Resonance Spectroscopy (MRS), a noninvasive technique that quantifies several endogenous neurochemicals, …show more content…
Although single voxel MRS generates spectra with high signal-to-noise ratio, a single MRS voxel cannot be placed in a homologous brain region because of differing brain size and gray matter gyration across individuals. Furthermore, an MRS voxel across participants will contain differing amounts of gray and white matter, with each tissue type containing differing amounts of metabolites will contribute differentially to MRS signal. Therefore, variability in placement and amounts of differing tissue types increases variability in metabolite levels ascertained from single voxel MRS, decreasing statistical power to detect abnormalities in metabolite levels. Second, extant studies often used a case-control design where MR data were acquired only once in each participant. These studies therefore can assess only associations, but not causal relations, between metabolite levels and mechanism of illness. Third, although treatment response and symptoms across unipolar depression fall along a continuum, abnormalities in brain structure, function, and metabolism in DD may differ from those in MDD. Brain abnormalities in DD therefore cannot be inferred from studies of MDD. For example, we showed23 that individuals at high risk for MDD compared with those at low risk had thinner cortex in the right hemisphere of the brain, whereas patients with DD had thicker cortex across large portions of the brain24. Similarly, metabolic abnormalities in
According to the Anxiety and Depression Association of America, depression is the leading cause of disability in America for people ages 15 to 44. Unfortunately, it is still widely misunderstood, which causes people to neglect themselves. There are so many different forms, the most major two being major depressive disorder and dysthymia. Symptoms can vary in the way they manifest themselves, and causes are still widely unknown. Luckily, there are many treatment options available. Understanding depression is the best way to combat it.
1. The meaning of Duchenne muscular dystrophy is a severe form of muscular dystrophy caused by a genetic defect that can be characterized by a disturbed growth of cardiac and skeletal muscles. It usually affects boys. In 1861, a French neurologist, Guillaume B. Duchenne, was the first person to give a detailed description of this syndrome.
Participants would be provided with a consent for them to participate, and this form would indicate a description of the research. After obtaining the consent form, both caregiver and participants would be informed that the surveys are anonymous. During the completion of the surveys, the participants will be instructed to complete the entire survey with accurate information. In addition, I would inform the participants that they will not be time, and the surveys can be discontinued at any time.
Cognitive dysfunction is a hallmark feature in neuropsychiatric disorders. Especially, domains including working memory, executive function, attention and information processing are defective.Deficits are observed in multiple domains, including working memory, executive function, attention and information processing. Disability caused by cognitive dysfunction are is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are
Duchenne Muscular Dystrophy (DMD) is a lethal genetic X-linked disease results from the mutation in the reading frame of the dystrophin protein, and it affects mostly boys in their muscle and cardiopulmonary function. Although there are no effective treatments to cure DMD patients right now, scientists consistently explore more methods to come up with the practical treatments. One of the most popular and valid approaches is a gene-editing therapeutic method – CRISPR/Cas9 Genome Editing. It adapts from the natural systems in bacteria, and it can generate targeted gene modifications to target specific DNA sequence. Then it introduces shifts within exons to restore the reading frame, so it can express a partial functional dystrophin protein.
I remember replying to a few of your posts last semester. Did you know Duchenne Muscular Dystrophy affects more boys than girls? Expect them to be in a wheel-chair at around during their early teens. It is also know that it takes longer for them to start walking, which means they barely walk during their lives. They even have a hard time raising their arms and fall often if they were walking. They might struggle to climb up the stairs or it may not even be worth the trouble. The worst case scenario is Cardiopathy because DMD causes damage to the heart. To further elaborate, the lacking of dystrophin results to weakening of the muscle layer in the heart which is called myocardium. This situation could indeed threaten their life. DMD has also affected the way they learn verbally and they even have a hard time focusing. In addition, they will struggle to recall memories and could interact emotionally different than most people (MDA For Strength, Independence & Life, 2016). I’d choose adoption if I could have avoided this devastating syndrome. I would also suggest prenatal diagnosis.
While reading about my classmates’ fears this week I have realized that we are all about to embark on a journey that is nerve-racking and exciting at the same time. Every one of us fears something different but we all have something in common. This fall we will all be trying something new and unfamiliar, something that we have never done before but have been planning for years. We are all afraid of what is about to happen and what to expect, but we all have our own distinct fears that we are unsure who relates with them. There are similarities and differences with the fears that my classmates and I have, as well as first year students all over the nation.
Thank you for your post. I agree that in your scenario, the counselor should consult with her colleagues to get their opinion. It may be harmless, but in ACA code of ethics (2014) section A.6.a previous relationships, counselors should consider the risks and benefits of accepting as clients those with whom they have had a previous relationship. If Jennifer chooses to except Grace invitation for coffee, she should document to cover herself. In section A.6.c, documenting boundary extensions, if counselors extend boundaries that are described in sections A.6.a and A.6.b, they must officially document, prior to interaction.
segawa's dystonia, which is a hereditary movement disorder. In addition, L-DOPA can also be used for treatment of restless leg syndrome. Formation of aspartame by transformation using thermolysin is another such example where thermolysin can be synthesized by Bacillus stearothermophilus and Thermoactinomycetes thalpophilus. Aspartame is used as an artificial sweetner. In addition to being an antioxidant, carnosine has recently been discovered to be a natural anti-glycating agent as well i.e. it can react with carbonyl groups on proteins thereby delaying cell ageing or senescence. Carnosine also fights against cellular damage by helping the body to get rid of toxic metals, a process known as chelation. Excessive levels of these pro-oxidative metals (such as copper, zinc) and toxic heavy metals (such as lead, mercury, and nickel) have been linked to many illnesses such as Alzheimer’s, autism, Parkinson’s, dementia and schizophrenia, where carnosine can be used as an supplement.Organisms like Ochrobactrum anthropi, Sphingosinicella xenopeptidilytica are found to produce
Patients cannot always be saved, medical personnel can help patients understand their outcomes. In the listed scenario a 17 year old has Duchene Muscular Dystrophy and multi organ failure. Although the patient is alert, his health continues to decline. Medical personnel feel from a medical perspective they cannot save the patient. The patient is unaware of his declining condition, because his parents asked the medical personnel to remain optimistic and encourage the patient to work towards getting better. The nurse should help the parents understand that they are ethically obligated to be honest and forthcoming with patients. It is the patients’s right to know his medical diagnosis. When everyone is aware of the current medical state of the
Both structural and functional changes in the brain activity are considered the underlying pathophysiology of the disease (9).
It’s 2025, and a young couple sits anxiously in the waiting room of the geneticist’s office to learn the results of genomic tests on their growing embryos in petri dishes. They’ve been married for about five years, and, to their mothers’ reliefs, they’ve finally decided to have children. However, muscular dystrophy has been observed in Genevieve’s family and Alzheimer’s disease and Hodgkin’s Lymphoma in Tom’s. The doctor tested the embryos for the presence of genetic predispositions to these illnesses. He also tested for their genders, height, intelligence, and muscle tone. The couple will be able to select which embryos to keep for gestation and which to discard. This scenario inspires and invigorates some while mortifying others. Many see
The first nursing diagnosis is activity intolerance related to imbalance between oxygen supply and demand secondary to congestive heart failure as evidence by CPK 480, MB fraction positive, Troponin 25, EKG NSR 96, ST elevations I, AVL, V4-V6; rare unifocal PVC’s, requirement of two-pillows to sleep, SOB when walking two blocks, ankle edema worse when standing for prolonged periods of time and sub-sternal pain. Ms. J.K. is expected to keep activity level within tolerated means with gradual improvement of tolerance. Tolerance will be monitored by absence of SOB, fatigue and dyspnea on exertion as well as HR, BP and RR. The goal is for Ms. J.K. to perform activities without complications and gradually improve her activity level.
According to Morgan (2015), the neuroscience of depression has an emotional impact on many areas of the brain. The stressors in the hypothalamus pituitary adrenal axis initiate the release of the
The severity of depression has been supported through scientific evidence that indicates that depression has a biological basis in the brain of a depressed person along with psychological and social implications. Whilst there are many catalysts in a person’s life that can be identified as a possible root cause of depression, such as stressful life events or the death of a loved one, the issue is far more complex, as the biological triggers of depression are not as easily expressed, such as faulty mood regulation in the brain, vulnerable genetics in the DNA, and other medical problems. Many things are altered in the brain of the depressed person. Firstly, what most understand to be an imbalance in the levels of chemicals that regulate emotions, is in reality far more elaborate. The true issue surrounding the many chemicals involved inside and outside of the nerve cells that undergo numerous chemical reaction which make up the dynamic system that is responsible for mood, perceptions, and the way one experiences life you experiences life can be altered in different ways that affect how one lives. Along with the brains chemicals, the connections between nerve cells called neurons decrease and deteriorate, meaning the