The polycystic kidney disease is a genetic disease: the kidney tissue is replaced by various cysts. In nephrology it is usual to distinguish between the two forms of the disease, one of them, in particular, affects the adult, while the other is more typical of the newborn. The disease impairs the functioning of the kidneys. The causes of these problems are to be sought in a genetic mutation. The symptoms differ according to the stage of disease: it starts from abdominal pain, to reach even to infections that affect the kidneys and the urinary tract.
Causes:
In most cases, kidney cysts are isolated and have no clinical significance. In polycystic kidney disease the cause is a mutation in the PKD1 gene (chromosome 16) in 85% of cases and the PKD2 gene (chromosome 4) for the remaining 15% of
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Treatment There is no cure for polycystic kidney disease. Scientific research, in fact, failed to identify therapies that could be decisive. However your doctor may prescribe drugs or treatment to relieve certain symptoms. You have to treat hypertension with medications with ACE inhibitors or low-salt diet, the same way as kidney failure can be slowed with a lifestyle healthier, doing physical activity, and not smoking, eating fat-free foods.
Sometimes in old age you have to resort to dialysis. Against abdominal pain and lower back you can use the analgesics and to fight urinary infections the antibiotic. In some cases it is possible to resort to a surgical intervention, which may consist of a kidney transplant or in the emptying of the cysts. These operations, however, are only recommended in exceptional cases.
Prevention:
if you’ve polycystic kidney infection and you're considering having kids, a hereditary advocate can help you survey your danger of passing the sickness to your expected
People with this inherited disorder are likely to develop several kinds of tumors, including, in some cases, renal cell carcinoma.
This condition can be treated at anytime by an antibiotic like penicillin. Since this condition can damage the organs, it is better to get it treated sooner than later. It is also important to keep going back to the doctors to get blood work done repeatedly to make sure that the infection is totally cleared up.
Injury to the glomerulus and the tubules presents the onset of Intra-renal failure (Matzke, 2011). Some of the frequent causes for Intra-renal failure are glomerulonephritis; pyelonephritis; and tubular injury. Post-renal failure develops from things like ureteroliths, tumors, or anatomic impediments. Opposite of the acute form, the chronic form has a slow onset that has no early stage symptoms. It is important to know that following an acute episode a chronic renal episode often follows, and at this juncture the damage is irreversible. Glomerulonephritis and pyelonephritis combined, has been reported to be the forerunner in as much as half the cases from acute to chronic renal failure. Diabetes mellitus, renal vascular disease, such as atherosclerosis, hypertension, polycystic kidney disease, drug damage, and nephrolith are all examples of other causes of CKD (Pradeep, 2014). Biopsies of kidneys that suffered with CKD reveal smaller kidneys with scarring on the tubules.
Luckily, after the excruciating occurrence, the stone usually doesn’t damage anything. Sometimes there comes a situation where the kidney stone either becomes too big or for some reason gets wedged in the urinary tract and the pain worsens. Also, the urine begins to get backed up, and the bladder and urinary tract begins to get infected. Thus, an operation must be performed. Originally, they were removed, either by slicing the bladder or kidney open, or by shoving an instrument up the ureter. Fortunately, through the miracles of technology, one does not necessarily have to go through this “invasive” treatment. Instead, there is a treatment that uses shockwaves to slice up the stone. This is called kidney stone lithotripsy. A large machine uses sound waves to break up the stone into small fragments that can be more easily passed through.
Primary treatments include antibiotic therapy, Fluid resuscitation, and crystalloid. Potential treatments depending on patient status include vasopressors and steroids, ventilator, renal dialysis, blood transfusion, and surgery.
There is no cure for CKD however it can be treated to relieve symptoms and give the patient a better life and to stop the condition becoming worse. During the early stages of CKD treatments can be given by your GP and mainly involve lifestyle changes such as becoming healthy, doing more exercise and taking certain medicines to assist in controlling blood pressure which then prevents further damage to the kidneys. However if the disease gets worse to the point where the kidneys stop working and functioning properly either a kidney transplant or dialysis which will be explained more in D2 more and it can impact a patient’s life a lot.
In this research paper I will attempt to discuss the causes, symptoms and signs of Polycystic Ovarian Syndrome, as well as how it is diagnosed and treated. As someone who is suffering from this disease, I found my research to be very informative and educational, raising awareness for my own understanding, and it is my intention to ensure that this same awareness is translated in my research paper.
Chronic Kidney Disease (CKD) is a disease that is described as a loss of kidney function gradually over time. As kidney function decreases, the waste collection in the body’s blood becomes high and makes the individual feel sick. This disease can lead to other complications in the body such as anemia, poor nutritional health, high blood pressure, and nerve damage. These complications will begin to progress and show as CKD progresses to advanced stages. Early detection of this disease is essential when it comes to treatment. If CKD is diagnosed early enough the disease progression can be slowed down and managed. This disease will eventually lead to failure of the kidneys
obstruction to the kidneys, an imaging test which include CT scans or MRI to reveal a more
Phenylketonuria, otherwise known as PKU, is a rare genetic disease that is caused by a person’s body being unable to metabolize the amino acid phenylalanine. The disease can cause mental retardation because the build up of phenylalanine in the body. When phenylalanine is not broken down and turned in a different amino acid, tyrosine, it can create other enzyme routes that build up in the blood stream and body tissue. This can be extremely harmful to the body and its development. This disease is caused by missing the enzyme phenylalanine hydroxylase, this enzyme is the one that normally breaks down phenylalanine. It is rare for this enzyme to be completely absence, but this form leads to the most severe mental
Drug therapy consists of; Lasix, antihypertensives, antiemetics, H-2 blockers, erythropoietin, vitamins and electrolyte balancing agents (phosphate, calcium, V-D, Vit-B, and amino acids. Dialysis is mostly the patient’s only way of survival. Nutritional therapy is encouraging patients to avoid ↑Ca and ↑ protein foods. Fluid restriction is important since the kidneys have a difficult time excreting. If left untreated the patient would essentially die. The fluid overload combined with the toxicity of the left over wastes would shut down the body’s organs and death would occur.
Chronic Kidney Disease (CKD) is among the leading causes of mortality throughout the world, and its prevalence and the health care costs resulting from it are considerable and increasing. CKD commonly is silent and asymptomatic until its late stages. Accordingly, CKD is diagnosed prior to symptomatic stage of kidney failure, resulting in delays in proper interventions and the emergence of adverse consequences in the CKD patients
Nephrotoxins, acute interstitial nephritis, glomerular damage, and vascular damage also correlate with intrarenal acute renal failure (Singh, Levy, & Pusey, 2013). Postrenal acute renal failure is usually a result of a urinary tract obstruction that affects the kidneys bilaterally, which causes the intraluminal pressure upstream from the site of the obstruction to increase with a progressive decrease in the glomerular filtration rate (McCance, Huether, Brashers, & Rote, 2014). A pattern consisting of several hours of anuria with flank pain followed by polyuria is typically found in individuals with postrenal acute renal failure (McCance, Huether, Brashers, & Rote, 2014).
There is a pair of kidneys in the human body. They are situated towards the back of the body under the ribs, just at the level of the waist where one on either side of the body. Each kidney is composed of about one million units which are called nephrons and each nephron consists of two parts: a filter which is called the glomerulus and a tubule leading out from the nephron (Cameron 1999). According to Marshall and Bangert (2008) the kidneys have three major functions. Firstly, the kidneys are excretion of waste from plasma in the blood. The second function is that, they maintain of extracellular fluid volume and composition. Lastly, the kidneys have a role in hormone synthesis.
Hemodialysis (HD) is one of several renal replacement therapies used for the treatment of end stage kidney disease (ESKD) and kidney failure. Dialysis removes excess fluids and waste products and restores chemical and electrolyte balance. HD involves passing the patient’s blood through an artificial semipermeable membrane to perform the filtering and excretion functions of the kidney. One important step before starting regular hemodialysis sessions is preparing the vascular access; ideally, a vascular access should be placed weeks or months before you start dialysis. The