Essay On Stem Cell Transplants

Stem cell research has been quite a controversial topic since its origin in the 1960s by Gopal Das and Joseph Altman. Of course, anything that uses a human embryo would be. Stem cell research could open a vast number of new doors for modern science, it could let us test new drugs, one of which could be the unfound cure for AIDS or Alzheimer’s disease. However, this branch of science comes at a high price, the price of a human life that is only five to six days

Stem cell research is the future of medical and biological research and remedies, and it is fascinating to watch the progression of this new and important science as it unfolds. These cells were discovered in mouse embryos in the 1980s, and are remarkable because of their potential to grow into a variety of different kinds of cells within a body. Common in fetuses, and more rare in adult animals of all kinds, stem cells can be manipulated in useful ways to repair many tissues, dividing limitlessly for therapeutic purposes. When a stem cell divides, each new cell has the potential either to remain a stem cell or to differentiate into more specialized tissue, such as nerve, pancreas, bone marrow, or unique blood components. Initially

What causes this disease is, after the transplant is complete the cells, of the transplanted bone marrow or stem cell, start attacking the recipient’s body. GVHD has a wide range of how dangerous it can be to the patient’s life, it can range from mild, where it is easily treatable, to life threatening, where there is no stopping the donor cells from attacking the recipient’s body. A biopsy on an affected organ can determine diagnoses of GVHD grade from I (mildest) to IV (most severe). To prevent GVHD, a couple of days before the transplant multiple drugs are prescribed to the patient: cyclosporine and methotrexate, tacrolimus and methotrexate, tacrolimus and mycophenolate mofetil, or prograf and sirolimus. These drugs are to lower the immune system from attacking the donor’s cells. The outlooks of a patient after the transplant is determined on how severe GVHD is and how closely match the bone marrow tissue or cell was. There have been some cases where GVHD caused damage to the liver, lungs, digestive tract and other organs. However, if this does happen or the patient start developing symptoms of GVHD, there are treatments. But the treatments does not always guarantee that the transplant will treat the original disease that was meant for the bone marrow tissue or cell transplant.

For a bone marrow transplant to work at it’s best you need to be a match with the person, which is usually a relative, who is donating the bone marrow, however some people do a bone marrow transplant with only 50% compatibility rate, but may result in GVHD/Graft Versus Host Disease. This means that the person is not a perfect match, also mostly known as a mismatch. You will need to have anti-rejection shots to prevent it getting worse. There is no set time when it can happen, as some happen shortly after, while others don’t have it for months after the transplant. It causes diarrhea, rashes and liver complications. It can be severe and could be life threatening. If it’s mild GVHD it’s completely a bad thing, as it removes any leftover

The use of stem cells has been highly controversial over the last few years, first it is important understand what they are and how they are used. A stem cell is a special cell that has no true function yet. Although all of the genes within a human stem cell can also become other types of cells.To get these cells from embryos we would have to kill it. Also, to get embryonic stem cells means doing an abortion. This has created a very hot topic, one side is in favor of their use, and the other side is very against it. Stem cells come at a high price, but is this price worth the people that can be helped by stem cells? This is the question that many people have been asking lately.

Stem cell research is surrounded by controversy, relating to the morality of the use of stem cells for medical procedures. This is often associated most strongly with embryonic stem cells, due to the fact that in order to harvest embryonic stem cells the formation of an embryo is necessary. Commonly it is argued that, since that embryo could have potentially became a human that it is unethical to destroy them for research. It is important to note that stem cell research in its very nature is unique from any other medical research, this is because stem cells are essentially blank slates of human cells, undifferentiated, meaning that these cells have potential to become

The society has evolved over the decades. Medical advances, greater technologies, better understanding of the world around us, the sky is the limit! The progression of a society is astounding from where it was just twenty years ago. One is able to do things that the forefathers would have never dreamed! Science has discovered ways to travel to the moon and back, reach some of the deepest depths of the oceans and discover new species, and drive hybrid cars. The achievements of today’s society have reached a new high; however, with great achievement comes great questions of ethics.

Due to the potential therapeutic uses and the potential profit from stem cells, there has been an increased interest in stem cell research. While some progress has been made, we do not know nearly enough about how stem cells work to use them for the treatment of human diseases. However, there are researchers that claim that they have developed the technology to apply stem cells to the treatment of aging and diseases. Websites such as www.youngeryounger.com and www.medra.com state that they have created a miraculous medical cure, known as cellular therapy, which can treat just about any problem.

with cancer and other disorders of the blood and immune system” (“FDA Warns About Stem

When one thinks of fatal diseases, what comes to mind? Cancer? Organ failure? Brain damage? All of those things and more could be a thing of the past with the incredible potential of stem cell research. Stem cells are like blank cells that can take the form of other kinds of cells. This gives them the ability to heal damaged areas, or grow replacement tissue for tissue that has been diseased. Stem cells can come from several different places, some of which cause lots of controversy and ethical debate. Because of this, stem cell research is not federally funded by the United States government. But, stem cell research has tons of potential and should get more attention for the greater good of our future.

Allogeneic HSCT (hematopoietic stem cell transplantation) has been a path-breaking discovery in the field of hemato-oncology, proven to be a cure for many diseases like red-cell disorders and inborn errors. Technical and supportive care has resulted in survival rates that exceed 70% within the first two years after HSCT. However, long-term survivors carry a high burden of morbidity, including infections, treatment related organ toxicities, musculoskeletal disorders, endocrinopathies and immunological complications like Graft-versus-Host-Disease (GVHD). These usually affect multiple organs and tissues, and exhibit a variable clinical course, but in any case there should be an early recognition and the treatment has to be one of an aggressive

Embryonic stem cell research is a highly controversial topic in today's society, this kind of stem cell commits to regenerate any type of tissue. Unfortunately, Embryonic Stem Cell Research has a dark side. To obtain these cells will kill the embryo automatically. In other words, the acquirement of the Human Embryonic Stem Cell includes performing an abortion. To obtain these cells, it would kill the embryo. This has created controversy since abortion is such a divisive topic. Politicians are uneasy to take sides. The Human Embryonic Stem Cell issue is today's Pandora's Box due to all the unwittingly chaos that it can bring to our lives. By having this new option available in the medical world,

Stem cells today have allowed doctors to conduct experimentations that could help discover the cure of various diseases that seem incurable. Through current clinical applications of stem cells, doctors have created various of stem cell therapy. Stem cell therapy is being use as a therapeutic option for a diverse group of genetic diseases such as cancer, Parkinson's, and muscular dystrophy. Cancer treatment most commonly uses somatic stem cells to decrease the amount of defective cells. Take leukemia for example. Leukemia is a type of cancer that is caused from leukocyte. What doctors first try on patients with leukemia is chemotherapy. IF chemotherapy does not reduce the sickle cells, then there is alternative procedures in place, it would

This paper will be discussing the history of stem cells. There are many different ways to collect stem cells. Stem cells can be used for either right or wrong reasons. People can either use them to cure or to cause harm. Most people use stem cells to cure fatal illnesses. The one researcher that put stem cells out in the science world so people could understand it better was Leroy Stevens. His first encounter with stem cells was with a mouse that had a teratoma.

The eight transiently chimeric patients resumed endogenous hematopoiesis and were maintained on low-dose tacrolimus monotherapy. Despite donor specific hyposensitivity in mixed lymphocytic reaction (MLR) and cytotoxic mediated lympholysis (CML) assays, transiently chimeric patients showed subclinical rejection on protocol renal biopsy, making IS withdrawal an unnecessary risk . This approach is different from the MGH group which concluded that durable chimerism is not necessary for IS withdrawal and transiently chimeric patients may also be weaned off IS(98). Two NU transiently chimeric subjects developed late (> 4 years post-transplant) acute rejection due to non-compliance with IS. GVHD was observed in two patients. Of these two, one patient developed grade 1-2 acute gastrointestinal GVHD which was controlled with steroids but the patient continued to have mild chronic GVHD. The second patient was diagnosed with combined gastrointestinal GVHD/CMV colitis. He presented late after onset of symptoms to a nontransplant hospital. He was given a presumptive diagnosis of colonic GVHD and started on high dose corticosteroids. He