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Gbc-0879 Case Study

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GDC-0879 is a potent, selective and orally bioavailable RAF small-molecule inhibitor. GDC-0879 effectively inhibited phospho-ERK with an IC50 values of 63 nmol/L and inhibited cellular viability of BRAF-mutant Malme3M cells with an EC50 values of 0.75 µmol/L. Moreover, there was a strong correlation between activating mutations of the BRAF oncogene and GDC-0879

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