Genetic Disorders: Sickle Cell Anemia And Disease

Sickle Cell Anemia is a group of disorders that cause red blood cells to become misshapen and break down. Sickle Cell Anemia affects many people all over the world; Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Ashley-Koch, Yang and Olney). Sickle Cell Anemia causes your red blood cells to be thin, stiff, and shaped like a sickle. But your red blood cells are supposed to be round and soft. When a person is diagnosed with sickle cell anemia the blood cells start to become clogged blood vessels, which can cause a great amount of health issues including: infections, stroke, and acute chest syndrome. People get sickle cell anemia by inheriting a mutated gene from both of their parents. On the down side, there is not currently an effective cure for sickle cell anemia, there are several different therapeutic approaches to treating and attempting to cure the disease and help people who are affected with sickle cell anemia better manage their symptoms. There have also been several great scientists that dedicated a lot of research to help find a cure for sickle cell anemia.

Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. The shape

This mutation paper is to give information on the Sickle Cell disease. This is a negative disease to have because the Sickle Cell Disease decreases the health of the person that has the disease and limits what they can and cannot do. Sickle Cell Disease is a red blood cell disease that causes ab normal hemoglobin to from in the veins. Hemoglobin is the protein that carries oxygen throughout the body to help with the respiratory system. The cause of the genetic mutation is inheritance or getting the disease from the parents the disease is found on chromosome 13 while the hemoglobin is still in beta phase on gene HB A. The disease typically shows symptoms within the first 5 to 6 months of birth and being diagnosed with Sickle Cell Disease. The symptoms include painful swelling on the hands and feet, and Jaundice, which causes a white color to form under the eyes, and turns the skin color yellow.

In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid "sickle" shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking to form a helical shape. Once this happens the cells cluster together and elongate and the cells start to "sickle". A person who has sickle cell anemia can only get it if both of their parents carry the sickle cell trait, if only one parent has the trait then there children are at risk for having the trait.

The Sickle Cell gene needs to be inhered from both of the parents; otherwise the individual will only carry the Sickle Cell trait. If the sickle cell trait is carried by an individual they can be asymptomatic. This individual can, however, transfer the gene abnormality to any offspring that they have. Sickle Cell Anemia is the most common form of sickle cell disease. It is also the most severe form of the disease. One variation of sickle cell anemia is hemoglobin SC disease and is one of the more common variations. Many times it manifests with a lesser degree of hemolytic anemia (1).

Sickle cell disease is an inherited form of anemia. This means both parents must pass on the defective gene for a child to be affected. The gene is more common in families that come from Saudi Arabia, Africa, Mediterranean countries, India, the Caribbean islands, and North, South, and Central America of African descent.

Sickle cell disease is categorized as an autosomal recessive disease. That means in order for one to inherit the disease, they must inherit two recessive alleles for sickle cell disease, or hemoglobin S gene. Having only one recessive allele makes you a carrier. The disorder causes the affected person’s red blood cells to disfigure into a crescent or sickle, which differs from the normal red blood cells that shaped into a doughnut. Sometimes, cells in a sickle shape cannot get through the narrow passageways of the blood vessels as easily as normal red blood cells. This blocks blood from entering and oxygen can’t reach the affected person’s organs. It can also crystallize and block arteries and

Sickle cell disease is a hereditary blood disorder caused by an abnormal hemoglobin in the red blood cell. Hemoglobin is a type of protein that carries oxygen in the body. In order for someone to have sickle cell disease they would need to have been passed down from at each one of their parents, by inheriting a total of two hemoglobin genes. The fact that this is a hereditary disease means that it is not considered to be contagious. This disease comes in about six different forms, but the most severe of them all is sickle cell anemia. Sickle cell is an inherited disease that affects the red blood cells causing debilitating symptoms, however, with treatment people with this disease can quite possibly live an otherwise

Sickle Cell Disease, commonly referred to as Sickle Cell Anemia, is a blood disease which red blood cells form an abnormal sickle or crescent shape. Red blood cells carry oxygen to the body and are normally shaped like a disc. This disease is genetically inherited from both parents. If you inherit the sickle cell gene from only one parent, you will have sickle cell trait. People with sickle cell trait do not have the symptoms of sickle cell anemia.

The cause of sickle cell anemia is by a mutation gene. The gene tells your body to make hemoglobin. Hemoglobin is responsible for giving the blood its red color and allows the red blood cells to carry oxygen from your lungs to all the parts of your body. The sickle cell gene is passed down from one generation to the next and is inherited. It is called autosomal recessive inheritance. This happens when both the mother and father pass on the detective form of gene. If only one parent passes on the sickle cell gene to the child that means the child will have the sickle cell trait. People who have the sickle cell trait are carriers and can pass the defective gene to their children. Your ethnic background can put you at risk for sickle cell anemia.

Sickle cell anemia is an inherited disease causing red blood cells to malfunction. It is a disorder the affects hemoglobin the protein found in red blood cells. People with this disease genetically inherit this untypical hemoglobin. This means that it cannot be transmitted from one person to another like the flu virus. These people have what its called hemoglobin (s). What this does is that instead of the red blood cell being circle-shaped it would appear to be a half moon shaped cell. It is necessary for the cells to be round so that they would be able to pass though small and large blood vessels.

Sickle cell anemia (SCA) is an inherited disease of the blood that is characterized by the production of abnormal hemoglobin S causing the cell to acquire a sickle shape that prevents the smooth flow of blood to a major organ (Shea et al. 2017). The stress is usually caused by fever, infection or cold temperature, which lead to sickle cell crisis caused by hypoxia, dehydration, and acidosis (Barranger, 2017).

Sickle cell disease is a blood disorder in which red blood cells take on an abnormal shape. Sickle cell anemia is when the red blood cells hemolyze, or die. Sickle cell disease is inherited from generation to generation and is the most common in inherited blood disorders. An estimated 70,000-100,000 people in America are currently suffering from this disease, most of which are African Americans. One is diagnosed with sickle cell disease in early childhood generally around four months old when the signs and symptoms are presented. Because of its huge impact, the United States requires all newborns to be tested for this disease. [1] Sickle cell disease is known to affect, “approximately 1 in every 400-500 African American

This disease is a genetic disease and it is hereditary. It is inherited as an autosomal recessive disease. This means that in order to get the gene you must receive a recessive trait from your mother and your father. The parents could both be heterozygous for the trait and therefore not have the disease, but instead they would both be a carrier. There are only a few ways that the parents could possibly pass the trait. One possibility of having a child with sickle-cell disease is if both parents are heterozygous and they both pass on their recessive allele, (25% chance for offspring to have sickle-cell disease). Another possibility

Sickle Cell Anemia is a group of disorders that cause red blood cells to become misshapen and break down. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Ashley-Koch, Yang and Olney). Sickle Cell Anemia causes your red blood cells to be thin, stiff, and shaped like a sickle. But your red blood cells are supposed to be round and soft. A person that is diagnosed with sickle cell anemia, their blood cells start to become clogged, causing blood clots, which can cause a great amount of health issues including: infections, stroke, and acute chest syndrome. People get sickle cell anemia by inheriting a mutated gene from both of their parents. On the down side, there is not currently an effective cure for sickle cell anemia, there are several different therapeutic approaches to treating and attempting to cure the disease and help people who are affected with sickle cell anemia better manage their symptoms. There have also been several great scientists that dedicated a lot of research to help find a cure for sickle cell anemia.