research that could have an impact on modern society. Taking course after course, learning basic biology, to medical physiology, and eventually applying those concepts into my own research. Mouse lung tissue is the starting point of my research. By creating a histological slide of this lung tissue, I was able to have a control for a healthy mouse lung. Identifying major structures such as, bronchi, bronchioles and alveoli. My intent for this research is to apply my findings, and compare them to other
In addition to peptides, protein-based ligands such as Affibody proteins have been utilized for tumor targeting. Anti-epidermal growth factor receptor (EGFR) Affibody protein (e.g., Ac-Cys-ZEGFR:1907, amino acid sequence: Ac-CVDNKFNKEMWAAWEEIRNLPNLNGWQMTAFIASLVDDPSQSANLLAEAKKLNDAQAPK-NH2) is used to target EGFR that is overexpressed in a wide variety of human tumors. Cheng and co-workers used anti-EGFR Affibody protein as tumor-targeting ligand on 64Cu–Au-IO nanoparticles (PET component: 64Cu, MRI
Evolution occurs when an animal species develops new bodily structures and functions in order to adapt to their new environment. These developments are seen as positive adaptations that enhances survival. However, some animal species have lost these new developments. Based on the geographic location and climate, some evolutionary developments that are no longer needed are lost due to the fact that the new bodily structure itself does not enhance the chance of survival in a particular environment
detected as early as week six and possibly earlier from vaginal and anal tracts according to our more recent studies (unpublished observations). The viral DNA may be from released free viral particles and infected exfoliated cells of these mucosal tissues. Further in situ hybridization, immunohistochemistry and transmission electronic microscopy confirmed the presence of viral DNA, viral capsid protein as well as viral particles. Therefore, this noninvasive sampling is feasible and effective for evaluating
infection and persistence. Recently, we have established a mouse papillomavirus (MmuPv1) oral infection model. Viral infection was detected at the human equivalent sites in the infected mice, and advanced dysplasia was identified in the infected tissues. This model holds the promise to mimic HPV-associated oropharyngeal cancers. More evidence demonstrates that tumor microenvironment has played a role in tumor outgrowth and progression. Multiple host defense systems, including host immune system
Dr. Bagci has published numerous studies in informatics of radiology spanning from development of computer aided diagnosis systems for infectious diseases to general image analysis techniques in MRI, CT, PET, and histology images, and development of image enhancement and reconstruction methods both in clinical, pre-clinical, and technical fields [11-65]. His works appeared in top-tier journals such as Nature Communications, IEEE Transactions on Medical Imaging, Journal of Virology, Journal of Pathology