Huntington's Disease Research Paper

Huntington’s disease, named after George Huntington, was discovered in 1872. It is a neurological condition that is caused by an altered gene. This gene is passed from parent to child, but the disease cannot be seen until a later age. As the disease affects the brain by death of brain cells, the patient loses thinking. Also loss of physical and emotional functions such as walking, feeling pain, and lack of display of emotion. The symptoms start to appear when adults are around the age of 30 as well as up to 70. The most common symptom of Huntington’s is chorea. Chorea is where the body jerks, usually in the arms and legs. They may also experience difficulty speaking, swallowing, and focusing.

Huntington’s disease is a progressive neurodegenerative disease that causes uncontrolled physical movements and mental deterioration. Huntington’s destroys the brain leading to changes in personality and even cognitive functioning. A faulty gene is responsible for this disease. This faulty gene generates a malformed protein which is accountable for the immediate damage. This damage leads to a slow decline and eventually death. Unfortunately there is no cure and only minor treatments to manage

For our gene and protein lab, my group decided and I to research the deadly, yet rare, disease, known as Huntington's disease. Huntington's disease is an extremely rare condition when your nerve cells in your brain break down overtime. Also, “HD” has a treatment that could aid someone, but it unfortunately cannot be cured. Huntington’s Disease typically begins when someone is thirty or forty years of age and can last years to a life time.

Huntington’s disease, also known as Huntington’s chorea, is a rare pathology among the nervous system. With fewer than 200,000 US cases per year is an inherited condition in which nerve cells in the brain break down over a period of time. This disease will usually start to effect people when they are in their 30s or 40s. Huntington’s usually results in psychiatric symptoms, progressive movement and thinking. No cure to this disease exists but physical therapy, drugs, and talk therapy can help manage symptoms.

Huntington’s disease can cause cognitive, movement, and psychiatric disorders. Some of the movement disorders a person can have when they are diagnosed with Huntington’s disease are unconscious jerking of the body, the person’s movements are slower, and they have a difficult time trying to talk or swallow. Some of the cognitive disorders that they can have are having a hard time being organized, formulating, and concentrating on tasks they are given, and they also are very impulsive and this can lead to outbursts. They also have a hard

Huntington’s is named after George Huntington who was the first person to describe the disease in 1872. However it wasn’t until 1993 that the gene that causes Huntington’s was discovered. Huntington’s is an inherited progressive disease that affects the brain and causes severe cognitive decline. The result is involuntary movements, emotional disturbance, damaged perception and memory as well as overall lowered though processing ability.

Most people who are affected with Huntington’s disease have the same physical type of effects. They usually have very random and jerky motions that they cannot control. They also

Huntington’s disease is a chronic and fatal neurological disorder caused by a trinucleotide repeat. It is caused by a genetic defect on chromosome four that causes a CAG repeat. When the number of repeats exceeds a certain amount, a neurological disease results. In a normal person, this section of DNA is repeated 10 to 35 times, but in a person with Huntington’s disease it is repeated 36 to 120 times. The disease is genetic and is passed down in families. If one parent has Huntington’s disease offspring have a 50% chance of getting the disease. The average age of onset is 40 years and the disease progresses over 10 to 25 years.

Huntington's disease is a dynamic mind issue that causes uncontrolled movements, frequent mood swings and loss of speculation capacity. Huntington's disease is acquired. This implies that the deficient quality that causes Huntington's disease is from a guardian to their child. If a parent has this dominant disease then the child has about a 50 percent chance of acquiring it. Regularly the indications of Huntington's disease in most cases begins when a person is in their 30’s. For some it can begin prior or later. Genetic testing allows individuals to see whether they have the disease or not. There is no cure for Huntington's disease. Medications can help deal with a percentage of the side effects, but can't stop the disease from occurring.

Huntington's Disease causes the progressive breakdown (Degeneration) of nerve cells in the brain. Huntington's disease has a big impact on a person's functional abilities and usually results in movement, thinking, and psychiatric disorders. When the disease develops before age 20, the condition is called juvenile Huntington's disease. An earlier emergence of the disease often results in a somewhat different set of indications and faster disease progression. Huntington’s Disease mostly causes movement, thinking, and psychiatric disorders with a wide spectrum of signs and symptoms. Some symptoms include Movement Disorders which can lead to involuntary jerking or writhing movements and difficulty with the physical production of speech or swallowing. Thinking Disorders which make you have a lack of awareness of one's own behaviors/abilities and slowness in processing thoughts or have trouble finding words. It also can make you have Psychiatric Disorders which can make you have a feeling of sadness or irritability, Fatigue, and loss of energy, and frequent thoughts of death, dying or suicide. Now for the causes of disease, Huntington's disease is caused by an inherited defect in a single gene. Huntington's disease is an autosomal dominant disorder, which means that a person needs only one copy of the defective gene to develop the disease. With the exception of genes on the sex chromosomes, A person inherits two copies of every gene, one copy from mom and one from dad. A parent with a defective gene could pass along the defective copy of the gene or the healthy copy. Each child in the family, Therefore, Has a 50 percent chance of inheriting the gene that causes the Genetic

Having Huntington's disease if very serious and over time can kill you. Huntington's disease is where your nerve cells in your brain slowly start to die off. When lots of your nerve cells die you get chorea. You’ll have random jerks in movement on the face, arms, neck. You will have a loss of mental function as well. This disease is genetically passed down too. The major cause is the abnormal huntingtin (mHtt) with more than 36 glutamine residues. The mHTT gene gives instructions for creating a protein called huntingtin. The gene's role is in the nerve cells in the brain. The symptoms of Huntington’s disease occur in personality, behavior and mental function. Common symptoms are hallucinations, depression, being irritable, not being able to remember, uncontrolled jerking movements. and loss of balance.

Huntington disease is a degeneration of the nervous system. It usually occurs in the older part of someone life. As the disease becomes worse it could cause uncontrollable movements in the body. Because the disease causes loss of brain cells, a person can lose memory. It can also contribute to depression. It takes about to ten to twenty years after the first signs of the disease for death to follow.

), Huntington’s disease (HD) is a fatal neurodegenerative disease that causes the progressive breakdown of nerve cells in the brain.

Huntington’s disease is a brain disorder, which is passed down from one generation to the next through irregular genes. Children who have parents suffering from Huntington’s disease have a 50% chance of having the gene that can later develop into the disease. The irregular genes are caused by a copying error in which a part of the gene is copied too many times. The disease slowly kills brain cells and causes a gradual progression in symptoms. Symptoms include things such as psychosis, hallucinations, involuntary movements, difficulty understanding things and confusion. In the early stages of Huntington’s disease symptoms are manageable, however as it progresses symptoms worsen and individuals can suffer memory loss and personality changes.

Huntington disease is a genetic disorder that has affect many people. The Huntington disease is commonly known as Huntington Chorea (Genetics Home Reference ). The disease was first recognized in 1872 by George Huntington (Phillips). George Huntington wrote a paper called On Chorea and “chorea” is Latin and Greek for chorus or a group of dances (Phillips). In the Middle Ages this term was given to many “dancing disorders” (Phillips). People with chorea basically had involuntary muscle jerking and twitches (Phillips).