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Leprosy: History, Prognosis, And Epidemiology

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Leprosy: History, Prognosis, and Epidemiology Leprosy has been in existence for several millennia. Its earliest records can be traced back to Egypt, India, and China. Some of the first known representations of the disease can be found in documents from these societies dating back as far 1550 B.C.E. ‘Throughout history, leprosy has been feared and misunderstood, and has resulted in significant stigma and isolation of those who are afflicted. It was thought to be a hereditary disease, a curse, or punishment from the gods. During the Middle Ages, those with leprosy were forced to wear special clothing and ring bells to warn others as they walked by’ (National Institute of Allergies and Infectious Diseases, “Leprosy”). To add to the even more …show more content…

It was the first bacterium to be identified as causing disease in humans. The organism has never been successfully grown on an artificial cell culture medium. Instead, it was grown in mouse footpads and in nine-banded armadillos because they, like humans, are susceptible to leprosy. Leprosy is a bacterial infection caused by an acid-fast bacillus bacterium known as Mycobacterium leprae (Microbe Wiki). It replicates intracellularly inside histiocytes and nerve cells and has two forms. One form is tuberculoid. Through this form M. leprae multiplies at the site of entry, usually the skin, invading and colonizing Schwann cells. The microbe then induces T-helper lymphocytes, epithelial cells, and giant cell infiltration of the skin, causing infected individuals to exhibit large flattened patches with raised and elevated red edges on their skin. The second form of leprosy is the lepromatous form. This form of the microbe proliferates within the macrophages at the site of entry. It also grows within the epithelial tissues of the face and ear lobes. Large numbers of M. leprae appear in the macrophages and the infected patients develop papules at the entry site, marked by a folding of the skin. Extensive penetration of this microbe may lead to severe body damage; for example the loss of bones, fingers, and toes. Leprosy …show more content…

They are as follows: muscle weakness, degeneration of vision, severe pain, and enlarged nerves. Another primary effect of leprosy is the attack on and weakening of the immune system. They demand an immune system response thus causing inflammation and neuropathy (Microbe Wiki). While these effects can vary, there is some ways in which clinicians have been able to classify them. There is, firstly, Type 1, which includes lesions, fluid accumulation, sensory loss, and neuropathy. This first type is considered the borderline type for leprosy. Secondly, there is Type 2, which is also known as Erythema nodosum leprosum. This type has a unique characteristic of having sudden onsets in patients and then subsiding just as quickly. General inflammation and red lesions are common in this type of patient. With this version there is also a likelihood of blindness due to inflammation of the eyes (Microbe

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